{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:45:38Z","timestamp":1767494738520,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":411,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study investigated the results of transanal total mesorectal excision (TaTME) combined with laparoscopy for locally advanced mid\u2013low rectal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with mid\u2013low locally advanced rectal cancer (T3 category or above and\/or N+) who underwent rectal resection with TaTME technique were enrolled prospectively. Patients who had distant metastasis, multiple malignancies, intestinal obstruction or perforation, or a clinical complete response to chemoradiotherapy were excluded. Postoperative results, including morbidity, circumferential resection margin (CRM) assessment, short-term survival and functional outcomes, were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-eight patients, with 25 mid and 13 low rectal tumours, who had elective resection by TaTME from March 2015 to September 2018 were included. There were 25 men and 13 women. Mean(s.d.) age was 58\u00b72(16\u00b74)\u00a0years and mean(s.d.) BMI was 24\u00b72(2\u00b75)\u00a0kg\/m2. Tumours were 3\u20139 cm from the anal verge. Mean(s.d.) duration of surgery was 210(42)\u00a0min. All patients had hand-sewn anastomoses and protective ileostomies. There were no conversions, abdominal perineal resections or postoperative deaths. Four patients had a complication, including three presacral abscesses, all managed by transanastomotic drainage. At 3 months after ileostomy closure, all patients had perfect continence. Apart from a greater tumour diameter in patients with low rectal cancers (6\u00b70 cm versus 4\u00b76 cm in those with mid rectal tumours; P\u00a0=\u00a00\u00b7035), clinical features were similar in the two groups. CRM positivity was greater for low than for mid rectal tumours (3 of 13 versus 0 of 25 respectively; P\u00a0=\u00a00\u00b7034), and more patients with a low tumour had TME grade 2 (4 of 13 versus 1 of 25; P\u00a0=\u00a00\u00b7038). There was no difference in oncological outcomes at 17 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although this study cohort was small, special attention should be paid to bulky low rectal tumours to reduce the rate of CRM positivity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs5.50234","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T08:34:17Z","timestamp":1574498057000},"page":"268-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transanal total mesorectal excision for locally advanced middle\u2013low rectal cancers"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-0804","authenticated-orcid":false,"given":"H H","family":"Thien","sequence":"first","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Hiep","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H","family":"Thanh","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N T","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T N","family":"Trung","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P T","family":"Vy","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P X","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Hieu","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Abdominal Emergency Surgery, Hue Central Hospital , Hue City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-6231","authenticated-orcid":false,"given":"N H","family":"Son","sequence":"additional","affiliation":[{"name":"Paediatric Centre, Hue Central Hospital , Hue City, 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