{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:36:54Z","timestamp":1790498214175,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010347","name":"Manufacturer Einar Willumsen's Memorial Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Program for Clinical Research Infrastructure (PROCRIN) established by the Lundbeck Foundation and the Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manufacturer Einar Willumsen's Memorial Fund"},{"name":"Program for Clinical Research Infrastructure (PROCRIN) established by the Lundbeck Foundation and the Novo Nordisk Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study aimed to identify the cumulative incidence and risk factors of metachronous peritoneal metastasis (M-PM) from colorectal cancer in patients who had intended curative treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with colorectal cancer were identified using the Danish Colorectal Cancer Group database for 2006\u20132015. The Danish Pathology Registry and the Danish National Patient Registry were used to identify M-PM to 2017. Risk factors were estimated by multivariable absolute risk regression, treating death and other cancers as competing risks. Overall risk and risk differences (RDs) were estimated at 1, 3 and 5 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 22 586 patients with colorectal cancer, the overall risk of M-PM was reported to be 0\u00b79 (95 per cent c.i. 0\u00b78 to 1\u00b70) per cent at 1 year, 1\u00b79 (1\u00b78 to 2\u00b71) per cent at 3 years and 2\u00b72 (2\u00b70 to 2\u00b74) per cent at 5 years. Advanced tumour category ((y)pT4 versus (y)pT1) increased the RD of both M-PM (2\u00b79 (95 per cent c.i. 2\u00b71 to 3\u00b77) at 1 year and 6\u00b70 (4\u00b79 to 7\u00b72) at 3 years) and lymph node involvement ((y)pN2 versus (y)pN0) (2\u00b75 (1\u00b78 to 3\u00b72) at year and 4\u00b73 (3\u00b72 to 5\u00b73) at 3 years). No further increase in risk was observed at 5 years. In a subanalysis, tumour-involved resection margin (R1 versus R0) was associated with M-PM with a RD of 3\u00b79 (1\u00b76 to 6\u00b72) at 1 year and 5\u00b79 (2\u00b76 to 9\u00b73) at 3 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The overall risk of M-PM in patients with colorectal cancer is low, but is increased in advanced T and N status. Follow-up of at least 3 years after colorectal cancer surgery may be necessary, given the potential curative treatment of early diagnosed M-PM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs5.50247","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T10:56:13Z","timestamp":1578567373000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Overall risk and risk factors for metachronous peritoneal metastasis after colorectal cancer surgery: a nationwide cohort study"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-2249","authenticated-orcid":false,"given":"S","family":"Ravn","sequence":"first","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital , Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Heide-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C F","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V J","family":"Verwaal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital , Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Hagemann-Madsen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lillebaelt Hospital , Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital , Aarhus, Denmark"},{"name":"Danish Colorectal Cancer Group , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"2022100812273606200_bjs550247-bib-0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/0284186X.2015.1131331","article-title":"Improved survival of colorectal cancer in Denmark during 2001\u20132012 \u2013 the efforts of several national initiatives","volume":"55","author":"Iversen","year":"2016","journal-title":"Acta Oncol"},{"key":"2022100812273606200_bjs550247-bib-0002","first-page":"B4428","article-title":"Aspects of survival from colorectal cancer in Denmark","volume":"59","author":"Iversen","year":"2012","journal-title":"Dan Med J"},{"key":"2022100812273606200_bjs550247-bib-0003","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ejso.2013.10.001","article-title":"Metachronous peritoneal carcinomatosis after curative treatment of colorectal cancer","volume":"40","author":"van Gestel","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"2022100812273606200_bjs550247-bib-0004","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/DCR.0000000000000412","article-title":"Epidemiology, management, and survival of peritoneal carcinomatosis from colorectal cancer: a population-based study","volume":"58","author":"Quere","year":"2015","journal-title":"Dis Colon Rectum"},{"key":"2022100812273606200_bjs550247-bib-0005","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/bjs.8679","article-title":"Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer","volume":"99","author":"Segelman","year":"2012","journal-title":"Br J Surg"},{"key":"2022100812273606200_bjs550247-bib-0006","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1046\/j.1365-2168.2002.02274.x","article-title":"Peritoneal carcinomatosis from colorectal cancer","volume":"89","author":"Jayne","year":"2002","journal-title":"Br J Surg"},{"key":"2022100812273606200_bjs550247-bib-0007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1586\/17474124.2016.1110019","article-title":"Improving oncologic outcomes for colorectal cancer at high risk for local-regional recurrence with novel surgical techniques","volume":"10","author":"Sugarbaker","year":"2016","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"2022100812273606200_bjs550247-bib-0008","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/bjc.2013.82","article-title":"Impact of peritoneal carcinomatosis in the disease history of colorectal cancer management: a longitudinal experience of 2406 patients over two decades","volume":"108","author":"Kerscher","year":"2013","journal-title":"Br J Cancer"},{"key":"2022100812273606200_bjs550247-bib-0009","first-page":"9286","article-title":"Update on the prevention of local recurrence and peritoneal metastases in patients with colorectal cancer","volume":"20","author":"Sugarbaker","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2022100812273606200_bjs550247-bib-0010","doi-asserted-by":"crossref","first-page":"51 200","DOI":"10.18632\/oncotarget.17158","article-title":"Colorectal cancer at high risk of peritoneal metastases: long term outcomes of a pilot study on adjuvant laparoscopic HIPEC and future perspectives","volume":"8","author":"Klaver","year":"2017","journal-title":"Oncotarget"},{"key":"2022100812273606200_bjs550247-bib-0011","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/SLA.0b013e31822638f6","article-title":"Results of systematic second-look surgery plus HIPEC in asymptomatic patients presenting a high risk of developing colorectal peritoneal carcinomatosis","volume":"254","author":"Elias","year":"2011","journal-title":"Ann Surg"},{"key":"2022100812273606200_bjs550247-bib-0012","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1245\/s10434-012-2473-5","article-title":"Definition of patients presenting a high risk of developing peritoneal carcinomatosis after curative surgery for colorectal cancer: a systematic review","volume":"20","author":"Honor\u00e9","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"2022100812273606200_bjs550247-bib-0013","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.ijsu.2014.07.014","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"12","author":"Vandenbroucke","year":"2014","journal-title":"Int J Surg"},{"key":"2022100812273606200_bjs550247-bib-0014","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2018.03.062","article-title":"Effectiveness of colorectal cancer screening in detecting earlier-stage disease-a nationwide cohort study in Denmark","volume":"155","author":"Larsen","year":"2018","journal-title":"Gastroenterology"},{"key":"2022100812273606200_bjs550247-bib-0015","author":"Danish Colorectal Cancer Group","year":"2015","journal-title":"National Guidelines for Diagnosis and Treatment of Colorectal Cancer"},{"key":"2022100812273606200_bjs550247-bib-0016","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/pds.1357","article-title":"Immortal time bias in observational studies of drug effects","volume":"16","author":"Suissa","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2022100812273606200_bjs550247-bib-0017","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/ajg.2015.210","article-title":"Understanding and avoiding immortal-time bias in gastrointestinal observational research","volume":"110","author":"Targownik","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2022100812273606200_bjs550247-bib-0018","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1445-2197.2010.05589.x","article-title":"South Australian clinical registry for metastatic colorectal cancer","volume":"81","author":"Neo","year":"2011","journal-title":"ANZ J Surg"},{"key":"2022100812273606200_bjs550247-bib-0019","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/sj.bjc.6604093","article-title":"Predictors of survival after hepatic resection among patients with colorectal liver metastasis","volume":"97","author":"Wang","year":"2007","journal-title":"Br J Cancer"},{"key":"2022100812273606200_bjs550247-bib-0020","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2147\/CLEP.S99481","article-title":"Danish Colorectal Cancer Group database","volume":"8","author":"Ingeholm","year":"2016","journal-title":"Clin Epidemiol"},{"key":"2022100812273606200_bjs550247-bib-0021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/CLEP.S9908","article-title":"Existing data sources for clinical epidemiology: the Danish National Pathology Registry and Data Bank","volume":"2","author":"Erichsen","year":"2010","journal-title":"Clin Epidemiol"},{"key":"2022100812273606200_bjs550247-bib-0022","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"2022100812273606200_bjs550247-bib-0023","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/CLEP.S49773","article-title":"Validity of the Danish National Registry of Patients for chemotherapy reporting among colorectal cancer patients is high","volume":"5","author":"Lund","year":"2013","journal-title":"Clin Epidemiol"},{"key":"2022100812273606200_bjs550247-bib-0024","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10985-013-9247-7","article-title":"Pseudo-observations for competing risks with covariate dependent censoring","volume":"20","author":"Binder","year":"2014","journal-title":"Lifetime Data Anal"},{"key":"2022100812273606200_bjs550247-bib-0025","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1177\/1536867X1501500313","article-title":"Regression analysis of censored data using pseudo-observations: an update","volume":"15","author":"Overgaard","year":"2015","journal-title":"Stata J"},{"key":"2022100812273606200_bjs550247-bib-0026","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.sla.0000197702.46394.16","article-title":"Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies","volume":"243","author":"Koppe","year":"2006","journal-title":"Ann Surg"},{"key":"2022100812273606200_bjs550247-bib-0027","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.3748\/wjg.v18.i39.5489","article-title":"Peritoneal carcinomatosis of colorectal origin: incidence, prognosis and treatment options","volume":"18","author":"Klaver","year":"2012","journal-title":"World J Gastroenterol"},{"key":"2022100812273606200_bjs550247-bib-0028","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/codi.12552","article-title":"Individualized prediction of risk of metachronous peritoneal carcinomatosis from colorectal cancer","volume":"16","author":"Segelman","year":"2014","journal-title":"Colorectal Dis"},{"key":"2022100812273606200_bjs550247-bib-0029","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1002\/ijc.25596","article-title":"Predictors and survival of synchronous peritoneal carcinomatosis of colorectal origin: a population-based study","volume":"128","author":"Lemmens","year":"2011","journal-title":"Int J Cancer"},{"key":"2022100812273606200_bjs550247-bib-0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.soc.2018.02.011","article-title":"Peritoneal metastases from colorectal cancer: treatment principles and perspectives","volume":"27","author":"Go\u00e9r\u00e9","year":"2018","journal-title":"Surg Oncol Clin N Am"},{"key":"2022100812273606200_bjs550247-bib-0031","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S2468-1253(19)30239-0","article-title":"Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial","volume":"4","author":"Klaver","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022100812273606200_bjs550247-bib-0032","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1001\/jama.2018.5623","article-title":"Effect of more vs less frequent follow-up testing on overall and colorectal cancer-specific mortality in patients with stage II or III colorectal cancer: the COLOFOL randomized clinical trial","volume":"319","author":"Wille-J\u00f8rgensen","year":"2018","journal-title":"JAMA"}],"container-title":["BJS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs5.50247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bjs5.50247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bjs5.50247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/4\/2\/284\/46350995\/bjs550247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjsopen\/article-pdf\/4\/2\/284\/46350995\/bjs550247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T12:38:01Z","timestamp":1665232681000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjsopen\/article\/4\/2\/284\/6061328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3,24]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs5.50247","relation":{},"ISSN":["2474-9842"],"issn-type":[{"value":"2474-9842","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"2019-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}