{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:56:47Z","timestamp":1785362207176,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Portal vein embolization (PVE) is performed to reduce the risk of liver failure and subsequent mortality after major liver resection. Although a cut-off value of 2\u00b77 per cent per min per m2 has been used with hepatobiliary scintigraphy (HBS) for future remnant liver function (FRLF), patients with perihilar cholangiocarcinoma (PHC) potentially benefit from an additional cut-off of 8\u00b75 per cent\/min (not corrected for body surface area). Since January 2016 a more liberal approach to PVE has been adopted, including this additional cut-off for HBS of 8\u00b75 per cent\/min. The aim of this study was to assess the effect of this approach on liver failure and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a single-centre retrospective study in which consecutive patients undergoing liver resection under suspicion of PHC in 2000\u20132015 were compared with patients treated in 2016\u20132019, after implementation of the more liberal approach. Primary outcomes were postoperative liver failure (International Study Group of Liver Surgery grade B\/C) and 90-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 191 patients with PHC underwent liver resection. PVE was performed in 6\u00b74 per cent (9 of 141) of the patients treated in 2000\u20132015 and in 32 per cent (16 of 50) of those treated in 2016\u20132019. The 90-day mortality rate decreased from 16\u00b73 per cent (23 of 141) to 2 per cent (1 of 50) (P = 0\u00b7009), together with a decrease in the rate of liver failure from 19\u00b79 per cent (28 of 141) to 4 per cent (2 of 50) (P = 0\u00b7008). In 2016\u20132019, 24 patients had a FRLF greater than 8\u00b75 per cent\/min and no liver failure or death occurred, suggesting that 8\u00b75 per cent\/min is a reliable cut-off for patients with suspected PHC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The major decrease in liver failure and mortality rates in recent years and the simultaneous increased use of PVE suggests an important role for PVE in reducing adverse outcomes after surgery for PHC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs5.50273","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T12:25:22Z","timestamp":1584447922000},"page":"449-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of structured use of preoperative portal vein embolization on outcomes after liver resection of perihilar cholangiocarcinoma"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-4571","authenticated-orcid":false,"given":"L C","family":"Franken","sequence":"first","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rassam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K P","family":"van Lienden","sequence":"additional","affiliation":[{"name":"Department Radiology and Nuclear Medicine, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Bennink","sequence":"additional","affiliation":[{"name":"Department Radiology and Nuclear Medicine, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Besselink","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O R","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"Gulik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P B","family":"Olthof","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands"},{"name":"Department of Surgery, Erasmus Medical Centre, Erasmus University , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"2022100812275629600_bjs550273-bib-0001","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/liv.14089","article-title":"Surgery for cholangiocarcinoma","volume":"39","author":"Cillo","year":"2019","journal-title":"Liver 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