{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:50:46Z","timestamp":1792669846990,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The role of antithrombotic chemoprophylaxis in prevention of venous thromboembolism (VTE) in laparoscopic surgery for gastric and colorectal malignancies is unknown. This study compared the addition of enoxaparin following intermittent pneumatic compression (IPC) with IPC alone in patients undergoing laparoscopic surgery for gastrointestinal malignancy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this multicentre RCT, eligible patients were older than 40 years and had a WHO performance status of 0 or 1. Exclusion criteria were prescription of antiplatelet or anticoagulant drugs and history of VTE. Patients were allocated to IPC or to ICP with enoxaparin in a 1 : 1 ratio. Stratification factors included sex, location of cancer, age 61 years and over, and institution. Enoxaparin was administered on days 1\u20137 after surgery. Primary outcome was VTE, evaluated by multidetector CT on day 7.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 448 patients randomized, 208 in the IPC group and 182 in the IPC with enoxaparin group were evaluated. VTE occurred in ten patients (4\u00b78 per cent) in the IPC group and six (3\u00b73 per cent) in the IPC with enoxaparin group (P\u00a0=\u00a00\u00b7453). Proximal deep vein thrombosis and\/or pulmonary embolism occurred in seven patients (3\u00b74 per cent) in the IPC group and one patient (0\u00b75 per cent) in the IPC with enoxaparin group (P\u00a0=\u00a00\u00b7050). All VTE events were asymptomatic and non-fatal. Bleeding occurred in 11 of 202 patients in the IPC with enoxaparin group, and one patient needed a transfusion. All bleeding events were managed by discontinuation of the drug.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n IPC with enoxaparin after laparoscopic surgery for gastric and colorectal malignancies did not reduce the rate of VTE. Registration number: UMIN000011667 (https:\/\/www.umin.ac.jp\/).<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bjs5.50323","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T08:49:42Z","timestamp":1595494182000},"page":"804-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intermittent pneumatic compression versus<\/i> additional prophylaxis with enoxaparin for prevention of venous thromboembolism after laparoscopic surgery for gastric and colorectal malignancies: multicentre randomized clinical trial"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-245X","authenticated-orcid":false,"given":"H","family":"Kamachi","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-9684","authenticated-orcid":false,"given":"N","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sunagawa City Medical Centre , Sunagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asahikawa-Kosei General Hospital , Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-9734","authenticated-orcid":false,"given":"Y","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, National Hospital Organization Hokkaido Cancer Centre , Hokkaido"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Surgical Centre , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Amano","sequence":"additional","affiliation":[{"name":"Clinical Research and Medical Innovation Centre, Hokkaido University Hospital , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Taketomi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"2022100813160784600_bjs550323-bib-0001","doi-asserted-by":"crossref","first-page":"132S","DOI":"10.1378\/chest.119.1_suppl.132S","article-title":"Prevention of venous thromboembolism","volume":"119","author":"Geerts","year":"2001","journal-title":"Chest"},{"key":"2022100813160784600_bjs550323-bib-0002","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00000658-198808000-00016","article-title":"Prevention of venous thromboembolism in general surgical patients. 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