{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:01:26Z","timestamp":1783609286171,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":150,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to determine the diagnostic accuracy of the faecal immunochemical test (FIT) for detecting colorectal cancer in symptomatic patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective study of patients with bowel symptoms. Stool samples were collected during rectal examination. The HM-JACKarc assay (Kyowa Medex, Tokyo, Japan) was used to quantify faecal haemoglobin (Hb); positive results were those with at least 10 \u03bcg Hb\/g faeces. Two-by-two tables and receiver operating characteristic (ROC) curve analysis were used to determine diagnostic accuracy; \u03c72 and Mann\u2013Whitney U tests were used to compare other parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 928 patients were included (M : F ratio 1 : 1\u00b75; median age 72 (i.q.r. 64\u201380)\u00a0years). The overall prevalence of colorectal cancer was 5\u00b71 per cent. The FIT had sensitivity of 85\u00b71 per cent, specificity of 83\u00b75 per cent, positive predictive value of 22\u00b76 per cent and negative predictive value of 99\u00b70 per cent. ROC analysis of FIT for diagnosing colorectal cancer gave an area under the curve value of 0\u00b789 (95 per cent c.i. 0\u00b784 to 0\u00b794). Significant bowel pathology was detected more frequently in FIT-positive patients (35\u00b71 per cent versus 7\u00b71 per cent in FIT-negative patients; P &amp;lt; 0\u00b7001). There were sex differences in FIT positivity (23\u00b77 per cent in men versus 17\u00b74 per cent in women; P\u00a0=\u00a00\u00b7019); the sensitivity of FIT for colorectal cancer in women was also low. False-negative FIT results were found mainly in women referred with iron-deficiency anaemia, who were found to have caecal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FIT effectively excluded colorectal cancer in symptomatic patients. Integration of FIT into the diagnostic pathway for colorectal cancer would direct resources appropriately to patients with a greater likelihood of having the disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs5.50346","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T06:17:21Z","timestamp":1600496241000},"page":"1180-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Accuracy of faecal immunochemical testing in patients with symptomatic colorectal cancer"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-2577","authenticated-orcid":false,"given":"A A","family":"Khan","sequence":"first","affiliation":[{"name":"Departments of Surgery, Conquest Hospital, St Leonards-on-Sea, and Eastbourne District General Hospital , Eastbourne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Klimovskij","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Conquest Hospital, St Leonards-on-Sea, and Eastbourne District General Hospital , Eastbourne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Harshen","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Conquest Hospital, St Leonards-on-Sea, and Eastbourne District General Hospital , Eastbourne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"2023020208202825900_bjs550346-bib-0001","volume-title":"Suspected Cancer: Recognition and Referral. 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