{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:21:11Z","timestamp":1697520071826},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem Molecular Bio Educ"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Students often have an oversimplified view of biological facts, which may hinder subsequent understanding when conceptual complexity gives rise to cognitive conflicts. To avoid this situation here, we present a PBL approach for the analysis of Ehlers\u2010Danlos syndrome (EDS), which integrates a variety of topics in cell biology, genetics, and molecular biology, and it is used to illustrate the inherent complexities in some classical biological concepts. Students of two different courses analyze phenotypic, cellular, and molecular characteristics of EDS. Effect of mutations on collagen synthesis on collagen genes' expression and regulation or on connective tissues is reviewed and discussed. Information retrieval is used to develop students' skills in web\u2010based molecular biology tools. Student interest and motivation is increased with the development of diagnostic protocols for a tissue biopsy and for an EDS causing mutation. Expected learning outcomes after completion of the project are also presented. Biochemistry and Molecular Biology Education Vol. 38, No. 6, pp. 410\u2010415, 2010<\/jats:p>","DOI":"10.1002\/bmb.20411","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T14:31:39Z","timestamp":1291127499000},"page":"410-415","source":"Crossref","is-referenced-by-count":0,"title":["My dog's cheeks: A PBL project on collagen for cell biology and genetics courses"],"prefix":"10.1002","volume":"38","author":[{"given":"Alberto Vicario","family":"Casla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Smith","family":"Zubiaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/tea.10099"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.20367"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:RISE.0000021001.77568.b3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.97"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.43"},{"key":"e_1_2_5_7_2","volume-title":"The Tutor in PBL: A Novice's Guide. Program for Faculty development","author":"Allyn W.","year":"2009"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:EDPR.0000034022.16470.f3"},{"key":"e_1_2_5_9_2","unstructured":"Available at:http:\/\/commons.wikimedia.org\/wiki\/File:Ehlers\u2010Danlos_ Syndrome_1.jpg. (Accessed from 2010)."},{"key":"e_1_2_5_10_2","unstructured":"OMIM Ehlers\u2010Danlos syndrome. Available at:http:\/\/www.ncbi.nlm.nih.gov\/omim\/. (Accessed from 2010)."},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700100"},{"key":"e_1_2_5_12_2","unstructured":"ENTREZ database. Available at:http:\/\/www.ncbi.nlm.nih.gov\/sites\/gquery. (Accessed from 2010)."},{"key":"e_1_2_5_13_2","unstructured":"ENSEMBL database. Available at:http:\/\/www.ensembl.org\/index.html. (Accessed from 2010)."},{"key":"e_1_2_5_14_2","unstructured":"Primer3: Primer design webtool. Available at:http:\/\/frodo.wi. mit.edu\/primer3\/. (Accessed from 2010)."},{"key":"e_1_2_5_15_2","unstructured":"NEBcutter: Restriction enzyme cutter webtool. Available at:http:\/\/tools.neb.com\/NEBcutter2\/. (Accessed from 2010)."},{"key":"e_1_2_5_16_2","unstructured":"D.Kennedy A.Hyland N.Ryan(2008) Writing and using learning outcomes: A practical guide tuning educational structures in Europe. Available at:http:\/\/tuning.unideusto.org\/tuningeu\/. (Accessed from 2010)."},{"key":"e_1_2_5_17_2","unstructured":"B. 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