{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:18:35Z","timestamp":1765268315809},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochem Molecular Bio Educ"],"published-print":{"date-parts":[[2016,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To foster medical students to become physicians who will be lifelong independent learners and critical thinkers with healthy skepticism and provide high\u2010quality patient care guided by the best evidence, teaching of evidence\u2010based medicine (EBM) has become an important component of medical education. Currently, the teaching and learning of biochemistry in medical schools incorporates its medical relevance and applications. However, to our knowledge there have been no reports on integrating EBM with teaching and learning medical biochemistry. Here, we present a case study to illustrate the significance of this approach. This case study was based on a biochemistry\/nutrition question in a popular board review book about whether a homeless alcoholic man is <jats:italic>at risk<\/jats:italic> of developing a deficiency of vitamin E. The possible answers and explanation provided in the book raised a question about the correct answer, which provided us with an opportunity to adapt the philosophy and certain basic EBM principles to find evidence for the clinical applicability of a commonly taught biochemistry topic. The outcome of this case study not only taught us how to conduct an EBM exercise to answer a specific patient question, but also provided us with an opportunity for in\u2010depth teaching and learning of the medical relevance of a specific biochemistry topic based on the best clinical evidence obtained from a systematic research of medical literature. \u00a9 2015 by The International Union of Biochemistry and Molecular Biology, 44:95\u201398, 2016.<\/jats:p>","DOI":"10.1002\/bmb.20924","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T07:52:11Z","timestamp":1448265131000},"page":"95-98","source":"Crossref","is-referenced-by-count":4,"title":["Teaching and learning of medical biochemistry according to clinical realities: A case study"],"prefix":"10.1002","volume":"44","author":[{"given":"Joshua M.","family":"Jabaut","sequence":"first","affiliation":[{"name":"MD Class 2016, the George Washington University, School of Medicine and Health Sciences Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramzi","family":"Dudum","sequence":"additional","affiliation":[{"name":"MD Class 2017, the George Washington University, School of Medicine and Health Sciences Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Margulies","sequence":"additional","affiliation":[{"name":"MD Class 2016, the George Washington University, School of Medicine and Health Sciences Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshita","family":"Mehta","sequence":"additional","affiliation":[{"name":"MD Class 2016, the George Washington University, School of Medicine and Health Sciences Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine the George Washington University, School of Medicine and Health Sciences Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7023.71"},{"key":"e_1_2_8_3_1","volume-title":"EBM: How to Practice and Teach EBM Medicine","author":"Sackett D. 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