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Most primary cell cultures and cell lines are adherent cells which grow in monolayers on surfaces. However, other cells such as hematopoietic cells, certain tumor cells, and cells of the immune system are suspension cells which are anchorage\u2010independent which grow and divide in solution. THP\u20101 cells are a commercially available, spontaneously immortalized monocyte\u2010like cell line derived from the peripheral blood of a patient with acute monocytic leukemia. These cells are an excellent model for suspension cell culture and studies of the immune system. Researchers have used THP\u20101 cells to study the host response to implantable devices and biomaterials <jats:italic>in vitro<\/jats:italic>. Tissue contacting surfaces of implantable materials initiate a host inflammatory response characterized by many events, one of which includes macrophage attachment to the surface, which ultimately leads to degradation and failure of the material. Using the THP\u20101 adhesion assay embedded in this CURE, students can participate in the scientific process by testing substances which may prevent the host inflammatory response to implantable devices and biomaterials. \u00a9 2019 International Union of Biochemistry and Molecular Biology, 47(4):417\u2013425, 2019.<\/jats:p>","DOI":"10.1002\/bmb.21248","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T14:59:05Z","timestamp":1555685945000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Making it stick: A CURE designed to introduce students to the scientific process and the host response to foreign materials"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-1579","authenticated-orcid":false,"given":"Joshua B.","family":"Slee","sequence":"first","affiliation":[{"name":"Department of Natural Scienece DeSales University  Center Valley Pennsylvania 18034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline S.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Biology Penn State University  Lehigh Valley, Center Valley Pennsylvania 18034"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Vision and Change in Undergraduate Biology Eduction: A Call to Action","author":"Brewer C. 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