{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:36:32Z","timestamp":1747146992479,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009473","name":"Universidad de M\u00e1laga","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009473","name":"Universidad de M\u00e1laga","doi-asserted-by":"publisher","award":["UMA18\u2010FEDERJA\u2010146"],"award-info":[{"award-number":["UMA18\u2010FEDERJA\u2010146"]}],"id":[{"id":"10.13039\/100009473","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biochem Molecular Bio Educ"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A high variety of experimental model organisms have been used in developmental biology practical lectures. The work with developing embryos is crucial to make students aware of the multiple biological phenomena underlying normal animal embryogenesis and morphogenesis and represent a unique experimental platform to analyze the impact of molecular signaling in the regulation of all these processes. In particular, Biochemistry undergraduate students enjoy both practical and theoretical lectures on the molecular mechanisms of embryonic development, as that allows them for the integration of crucial molecular concepts (e.g. signaling and signal transduction mechanisms; molecular patterning of development) into the dynamic and progressive context of animal embryonic ontogenesis. Accordingly, it is important to carefully design practical laboratory lectures in developmental biology, as these are a unique pedagogical tools fostering the interests of the students in this subject. This study describes the design, implementation, and evaluation of a two\u2010session laboratory practical activity performed by Biochemistry undergraduate students at University of M\u00e1laga (Spain). In this practical activity, which takes advantage of the unique characteristics of the chick embryo, students learn how the vertebrate heart forms from the fusion of two bilateral\u2010symmetric cardiac progenitor pools under the guidance of the underlying endoderm. This cheap and easy practical laboratory activity provides relevant visual information on how experimental manipulations can severely influence anatomical form during organ development, as well as an excellent experimental setting to test molecular regulation of morphogenesis in an ex vivo (ex ovo) context.<\/jats:p>","DOI":"10.1002\/bmb.21549","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T14:02:11Z","timestamp":1624370531000},"page":"782-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Training biochemistry students in experimental developmental biology: Induction of <i>cardia bifida<\/i> formation in the chick embryo"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-0900","authenticated-orcid":false,"given":"Paul","family":"Palmquist\u2010Gomes","sequence":"first","affiliation":[{"name":"Department of Animal Biology, Institute of Biomedicine of M\u00e1laga (IBIMA), Faculty of Sciences University of M\u00e1laga  M\u00e1laga Spain"},{"name":"Area of Biotechnology, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND)  Campanillas, M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-7252","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"P\u00e9rez\u2010Pomares","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Institute of Biomedicine of M\u00e1laga (IBIMA), Faculty of Sciences University of M\u00e1laga  M\u00e1laga Spain"},{"name":"Area of Biotechnology, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND)  Campanillas, M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-6645","authenticated-orcid":false,"given":"Juan Antonio","family":"Guadix","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Institute of Biomedicine of M\u00e1laga (IBIMA), Faculty of Sciences University of M\u00e1laga  M\u00e1laga Spain"},{"name":"Area of Biotechnology, Andalusian Centre for Nanomedicine and Biotechnology (BIONAND)  Campanillas, M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797640"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2015.10.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.11.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(59)90019-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"}],"container-title":["Biochemistry and Molecular Biology Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmb.21549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmb.21549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmb.21549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:47:03Z","timestamp":1693345623000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/bmb.21549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/bmb.21549"],"URL":"https:\/\/doi.org\/10.1002\/bmb.21549","archive":["Portico"],"relation":{},"ISSN":["1470-8175","1539-3429"],"issn-type":[{"type":"print","value":"1470-8175"},{"type":"electronic","value":"1539-3429"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"2020-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}