{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:04:58Z","timestamp":1791317098120,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trichloroethylene (TCE) is a small halogenated compound that has been used extensively as a metal degreaser and a solvent for the past 100 years. As a result of its widespread use, TCE can be found in the groundwater of about one\u2010third of the hazardous waste sites on the United States Environmental Protection Agency's National Priorities List. Human exposure to TCE in the environmental media is of concern because TCE has been found to be carcinogenic in laboratory animals. This paper describes the development and validation of a HS\u2010SPME\u2010GC\/MS method for determination of TCE in rat plasma. The effects of different parameters such as sample volume, extraction and desorption conditions, fiber positions and salt addition were investigated and optimized. The method is rapid, simple, sensitive and requires a very small sample volume. The lower limit of quantitation was 0.25 ng\/mL and correlation coefficient (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>) values for the linear range of 0.25\u2013100 ng\/mL were 0.996 or greater. The precision and accuracy for intra\u2010day and inter\u2010day were better than 8.0%. This validated method was successfully applied to study the toxicokinetic behavior of TCE following low levels of oral administration. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1016","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T12:16:28Z","timestamp":1211890588000},"page":"977-984","source":"Crossref","is-referenced-by-count":6,"title":["Optimization, validation and application of a method for the determination of trichloroethylene in rat plasma by headspace solid\u2010phase microextraction gas chromatography mass spectrometry"],"prefix":"10.1002","volume":"22","author":[{"given":"Yongzhen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Muralidhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00453-2"},{"issue":"7","key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/clinchem\/40.7.1401","article-title":"Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure","volume":"40","author":"Ashley DL","year":"1994","journal-title":"Clinical Chemistry"},{"key":"e_1_2_1_4_1","volume-title":"Toxicological Profile for Trichloroethylene (updated).","author":"ATSDR","year":"1997"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459620701301763"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19991115)13:21<2133::AID-RCM764>3.0.CO;2-J"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00546-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/0306731031000104713"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408448909037475"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2241"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039890109604068"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.1.22"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.488"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1081\/CI-200048062"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287398509530688"},{"key":"e_1_2_1_16_1","unstructured":"2001 Office of Research and Development US Environmental Protection Agency Washington DC EPA Trichloroethylene Health Risk Assessment: Synthesis and Characterization. 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