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The sterochemical separation factor (\u03b1) obtained was 1.14 and the maximum stereochemical resolution factor (<jats:italic>R<\/jats:italic>) was 0.80 when using a mobile phase consisting of hexane: 2\u2010propanol: diethylamine (90:10:0.4) at 23\u00b0C. The hydroxy metabolite could not be successfully separted into its corresponding enantiomers under these chromatographic conditions. The method has been used to determine and identify the enantiomers of PRO and its hydroxy metabolite in a serum sample.<\/jats:p>","DOI":"10.1002\/bmc.1130070110","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T12:26:16Z","timestamp":1117283176000},"page":"38-40","source":"Crossref","is-referenced-by-count":11,"title":["Direct enantiomeric high performance liquid chromatographic separation of propafenone and its major metabolite in serum on a cellulose tris\u20103,5\u2010dimethylphenyl carbamate chiral stationary phase"],"prefix":"10.1002","volume":"7","author":[{"given":"Hassan Y.","family":"Aboul\u2010Enein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soliman A.","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530010409"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)93275-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719008052427"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719008052427"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198811000-00017"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/5.suppl_A.115"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530020107"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198734060-00001"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189604"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1985.97"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.5.1068"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","unstructured":"Lindner W.(1987). 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