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Mexiletine was simultaneously extracted and derivatized with carbon disulphide for separation and quantitation on a glass column (1.5 m \u00d7 3 mm i.d.) packed with 1.5% OV\u20101 coated on 80\u2013100 mesh Shimalite W (201D). The method required only 0.5 mL of plasma and could detect as little as 10 ng of mexiletine. 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