{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:32:57Z","timestamp":1768789977467,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T00:00:00Z","timestamp":1112745600000},"content-version":"vor","delay-in-days":3689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We found a high concentration (1030 pmol per pineal gland) of <jats:sc>D<\/jats:sc>\u2010aspartic acid (<jats:sc>D<\/jats:sc>\u2010Asp) in the pineal gland of 6\u2010week\u2010old Sprague\u2010Dawley (SD) rats. The content of <jats:sc>D<\/jats:sc>\u2010Asp decreased with age, being 210 and 33 pmol per pineal gland in 28\u2010 and 45\u2010week\u2010old rats respectively. The proportion of <jats:sc>D<\/jats:sc>\u2010Asp [(<jats:sc>D<\/jats:sc>\u2010Asp\/total Asp) \u00d7 100] also decreased with age, declining from 66% to 10% between 6 and 45 weeks after birth. The proportion of <jats:sc>D<\/jats:sc>\u2010Asp did not differ between the sexes. The concentration of <jats:sc>D<\/jats:sc>\u2010Asp was higher at night (at 2.00 a.m. 2830\u00b1485 pmol per pineal gland) than during the day (at 10.00 a.m. 1030\u00b1200 and at 3:00 p.m. 682\u00b1194 pmol per pineal gland), suggesting that biosynthesis of <jats:sc>D<\/jats:sc>\u2010Asp in the pineal gland occurs at night. <jats:sc>D<\/jats:sc>\u2010Asp was found to be distributed in the cytosol of pinealocytes, but its biological role remains unclear.<\/jats:p>","DOI":"10.1002\/bmc.1130090211","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T12:38:26Z","timestamp":1117283906000},"page":"106-109","source":"Crossref","is-referenced-by-count":74,"title":["Occurrence of <scp>D<\/scp>\u2010aspartic acid in rat brain pineal gland"],"prefix":"10.1002","volume":"9","author":[{"given":"Kazuhiro","family":"Imai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomofumi","family":"Santa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90149-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90908-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb13657.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3876.142"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(86)80329-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1130090103"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03219.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03575.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80286-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90476-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(01)93016-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-06-02087.1988"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90424-P"},{"key":"e_1_2_1_15_1","first-page":"35","volume":"21","author":"Reiter R. J.","year":"1986","journal-title":"J. Neural Transm."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83081-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700690153"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-5-1319"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122694"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"18361","DOI":"10.1016\/S0021-9258(19)36969-8","volume":"267","author":"Yamauchi T.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(91)90013-C"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41029-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07555.x"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.1130090211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.1130090211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:51:42Z","timestamp":1760035902000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.1130090211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/bmc.1130090211"],"URL":"https:\/\/doi.org\/10.1002\/bmc.1130090211","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}