{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:00:21Z","timestamp":1790262021589,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T00:00:00Z","timestamp":1112745600000},"content-version":"vor","delay-in-days":3505,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Differences in drug\u2010melanin interactions were determined for 13 phenothiazine neuroleptics and 2 dibenzazepine thymoleptics by means of high\u2010performace liquid chromatography. The chromatographic column was packed with a stationary phase obtained by chemical immobilization of synthetic <jats:sc>L<\/jats:sc>\u2010dopa melanin on silica particles. For six phenothiazines the melanin\u2010binding parameters were also determined by an ultrafiltration method. Correlation between measures of drug\u2010melanin interaction determined chromatographically and by the standard slow\u2010equilibrium method was significant, however moderate. The chromatographic method of assessing interactions between drugs\u2010melanin interaction determined chromatographically and by the standard slow\u2010equilibrium method was significant, however moderate. The chromatographic method of assessing interactions between drugs and melanin permitted reliable and quantitatively comparable data for representative series of solutes to be readily obtained. Such data were subjected to the analysis of quantitative structure\u2010retention relationships (QSRR). It was found that retention of the agents on the immobilized melanin column could be described by two\u2010parameter regression equations comprising the energy of the lowest unoccupied molecular orbital and either the water\u2010accessible surface area of a drug molecule or its hydrophobicity parameter, determined chromatographically on an immobilized artificial membrane column. The QSRR equation derived allows for the estimation of melanin binding based on the structure of a compound candidate, and thus rationalizes predictions of potential toxicity of drugs or drug candidates.<\/jats:p>","DOI":"10.1002\/bmc.1130090509","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T12:40:49Z","timestamp":1117284049000},"page":"233-237","source":"Crossref","is-referenced-by-count":25,"title":["Chromatographic modelling of interactions between melanin and phenothiazine and dibenzazepine drugs"],"prefix":"10.1002","volume":"9","author":[{"given":"Aleksandra","family":"Radwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Fra\u0327ckowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Fran\u00e7oise","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kaliszan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600661110"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/jid.1965.161","volume":"45","author":"Blois M. 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