{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:28:21Z","timestamp":1773847701298,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid and simple short\u2010end (reverse) capillary zone electrophoresis method was developed and validated for the separation and quantification of tetracaine in skin using tape samples. The separation was performed in a 485\u00a0mm (400\u00a0mm to window) \u00d7\u00a050\u00a0\u00b5m internal diameter fused silica capillary using a background electrolyte of phosphoric acid\u2013Tris pH2.5 at \u201325\u00a0kV. The extraction of tetracaine from tape samples was achieved using methanol diluted to 50% with water before injection. Procaine was the internal standard. The migration times for procaine and tetracaine were 1.25 and 1.36\u00a0min, respectively. The limit of quantification for tetracaine was 50\u00a0\u00b5g, with a signal\u2010to\u2010noise ratio greater than 10. The calibration curve was linear from 50 to 1200\u00a0\u00b5g with <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> greater than 0.99. The CV for both within\u2010 and between\u2010assay imprecision and the percentage inaccuracy for the quality control samples including lower and upper limits of quantitation were &lt;12.1% and &lt;11%, respectively. The absolute mean recovery of tetracaine was &gt;97%. The accuracy and selectivity of this method allowed the rapid measurement of tetracaine in tape samples obtained from a skin tape stripping study of local anaesthetics in healthy subjects. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1142","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T21:35:39Z","timestamp":1230154539000},"page":"488-491","source":"Crossref","is-referenced-by-count":5,"title":["Rapid analysis of tetracaine for a tape stripping pharmacokinetic study using short\u2010end capillary electrophoresis"],"prefix":"10.1002","volume":"23","author":[{"given":"F.","family":"Al\u2010Otaibi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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