{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:14:01Z","timestamp":1760645641283,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T00:00:00Z","timestamp":1226880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasmatic chlorophacinone is commonly measured with liquid chromatographic assay, which convenient but lacks sensitivity and selectivity and usually requires ion pair reagents to reduce the chromatographic tailed peak. In this paper, a novel method using eluent generator reagent\u2010free ion chromatography coupled with electrospray ionization ion trap mass spectrometric detection for the determination of chlorophacinone in plasma has been developed. After samples were extracted with 10% (v\/v) methanol in acetonitrile and cleaned by solid\u2010phase extraction, chromatographic separation was performed on an IonPac<jats:sup>\u00ae<\/jats:sup> AS11 analytical column (250\u00a0\u00d7\u00a04.0\u00a0mm) using 40.0\u00a0mmol\/L KOH containing 10% (v\/v) methanol as organic modifier. Quantification was performed by negative electrospray ionization in multiple reaction monitoring mode. The transition <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 373 \u2192 201 was for the quantification ion; the transitions <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 373 \u2192 172 and <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 373 \u2192 145, as well as the isotope ions <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 375 and <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 203, were for the qualitative ions. All the method parameters were validated. It was confirmed that this method can be used in clinical diagnosis and forensic toxicology. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1148","type":"journal-article","created":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T01:02:16Z","timestamp":1226883736000},"page":"524-530","source":"Crossref","is-referenced-by-count":6,"title":["Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass 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