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Separation of rifaximin from biological matrix was achieved by direct injection of rat serum and urine onto a restricted\u2010access medium, Supelco LC\u2010Hisep, a shielded hydrophobic stationary phase, using acetonitrile:water:acetic acid (18:82:0.1 v\/v\/v) as a mobile phase. The linear range was 0.10\u201320\u00a0\u00b5g\/mL (<jats:italic>r<\/jats:italic><jats:sup>2 <\/jats:sup>&gt;\u00a00.999, <jats:italic>n<\/jats:italic>\u00a0=\u00a06), intraday and interday variation was &lt;6.10%. The limits of detection and quantification were 0.03 (signal\u2010to\u2010noise ratio &gt;3) and 0.10\u00a0\u00b5g\/mL (signal\u2010to\u2010noise ratio &gt;10), respectively. The method was successfully applied to pharmacokinetic studies of rifaximin after an oral administration to rats. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1149","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T21:36:21Z","timestamp":1230154581000},"page":"563-567","source":"Crossref","is-referenced-by-count":17,"title":["Rapid determination of rifaximin in rat serum and urine by direct injection on to a shielded hydrophobic stationary phase by HPLC"],"prefix":"10.1002","volume":"23","author":[{"given":"R. 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