{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:23:43Z","timestamp":1772015023544,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sensitive and specific liquid chromatography\u2013electrospray ionization\u2013mass spectrometry method for the identification and quantification of pentoxyverine citrate and guaifenesin in human plasma has been developed. After extraction from plasma samples by ethyl acetate, the internal standard and analytes were separated by high\u2010performance liquid chromatographic on a Shim\u2010pack VP\u2010ODS C<jats:sub>18<\/jats:sub> column (150 \u00d7 2.0 mm) using a mobile phase consisting of A (methanol) and B (0.4% glacial acetic acid and 4 mmol\/L ammonium acetate) (A:B, 43 : 57). Analysis was performed on a Shimadzu LC\/MS\u20102010A in selected ion monitoring mode with a positive electrospray ionization interface. The method was linear in the concentration range of 1.0\u2013640.0 ng\/mL for pentoxyverine citrate and 0.025\u20136.4 \u03bcg\/mL for guaifenesin. The inter\u2010 and intra\u2010 precision were all within 12% and accuracy ranged from 85 to 115%.The lower limits of quantification were 1.0 ng\/mL for pentoxyverine citrate and 25.0 ng\/mL for guaifenesin. The extraction recovery was on average 81.95% for pentoxyverine citrate and 89.03% for guaifenesin. This is the first assay method reported for the simultaneous determination of pentoxyverine citrate and guaifenesin in plasma using one chromatographic run. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1298","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T03:03:44Z","timestamp":1248404624000},"page":"351-357","source":"Crossref","is-referenced-by-count":13,"title":["A sensitive liquid chromatography\u2013electrospray ionization\u2013mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma\u2014application to pharmacokinetic and bioequivalence studies"],"prefix":"10.1002","volume":"24","author":[{"given":"Jinhua","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(93)80072-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.1999.13.665"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01252-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.10.008"},{"key":"e_1_2_1_6_1","first-page":"284","article-title":"RP\u2010HPLC for rapid and simultaneous determination of three com ponents in Yuchuang Weilin Namin capsules","volume":"28","author":"Jiang Y","year":"2008","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"key":"e_1_2_1_7_1","first-page":"1","article-title":"Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model","volume":"6","author":"Kagan L","year":"2009","journal-title":"Pulmonary Pharmacology and Therapeutics"},{"key":"e_1_2_1_8_1","first-page":"1068","article-title":"Determination of guaifenesin in human plasma by LC\u2013MS\u2013MS and its pharmacokinetic study","volume":"18","author":"Liao QF","year":"2007","journal-title":"China Pharmacy"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80172-9"},{"key":"e_1_2_1_10_1","first-page":"1333","article-title":"Determination of pentoxyverine citrate tablets by ion\u2010pair RP\u2010HPLC","volume":"11","author":"Wu J","year":"2008","journal-title":"China Pharmacist"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2003.12.004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.17.1389"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2008.12.015"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.1298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.1298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:28:14Z","timestamp":1760038094000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.1298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,24]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1002\/bmc.1298"],"URL":"https:\/\/doi.org\/10.1002\/bmc.1298","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,24]]}}}