{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:07:19Z","timestamp":1761512839718,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T00:00:00Z","timestamp":1280102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of new (phenoxyethyl)aminoalkanol derivatives were synthesized and evaluated for their anticonvulsant activity. The most promising compound seemed to be (<jats:italic>R<\/jats:italic>,<jats:italic>S<\/jats:italic>)\u20101N\u2010[(2,6\u2010dimethyl)phenoxyethyl]amino\u20102\u2010butanol, which displayed anti\u2010MES activity (in mice, i.p.) with protective index (TD<jats:sub>50<\/jats:sub>\/ED<jats:sub>50<\/jats:sub>) of 5.712, corresponding to that of phenytoin (6.6), carbamazepine (4.9) and valproate (1.7). The lipophilicity of compounds <jats:bold>1\u201317<\/jats:bold> exhibiting anticonvulsant activity was investigated. Their lipophilicities (<jats:italic>R<\/jats:italic><jats:sub>M0<\/jats:sub>) were determined using reversed\u2010phase thin\u2010layer chromatography (RP\u2010TLC) with a mixture of acetone and water as mobile phases. The partition coefficients of <jats:bold>1\u201317<\/jats:bold> (log<jats:italic>P<\/jats:italic>) were also calculated using two computer programs (Pallas and ALOGPS) and compared with <jats:italic>R<\/jats:italic><jats:sub>M0<\/jats:sub>. The relationship between anticonvulsant activity and lipophilicity of the tested substances was estimated. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1453","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T22:19:30Z","timestamp":1280182770000},"page":"1365-1372","source":"Crossref","is-referenced-by-count":7,"title":["The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity"],"prefix":"10.1002","volume":"24","author":[{"given":"Anna","family":"Waszkielewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Szkaradek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"P\u0119kala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Galzarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Marona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)84246-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/208537a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0644"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600760902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00213a022"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Targets for antiepileptic drugs in the synapse","volume":"13","author":"Johannessen Landmark C","year":"2007","journal-title":"Medical Science Monitor"},{"key":"e_1_2_6_8_1","first-page":"8","article-title":"Diambutol synthesis","volume":"17","author":"Kalinina NN","year":"1963","journal-title":"Meditsinskaya Promyshlennost SSSR"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nrl.0000256353.14257.7c"},{"key":"e_1_2_6_10_1","first-page":"405","article-title":"Evaluation of some 2\u2010substituted derivatives of xanthone for anticonvulsant properties","volume":"53","author":"Marona H","year":"1998","journal-title":"Pharmazie"},{"key":"e_1_2_6_11_1","first-page":"487","article-title":"Synthesis and anticonvulsant activity of 1,2\u2010aminoalkanol derivatives","volume":"55","author":"Marona H","year":"1998","journal-title":"Acta Poloniae Pharmaceutica \u2013 Drug Research"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.039"},{"key":"e_1_2_6_13_1","unstructured":"MaronaH WaszkielewiczAandKie\u0107\u2010KononowiczK.Derivatives of aminoalkanols metod of obtaining aminoalkanols and their use. Patent WO\/2009\/093916 2009."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)00002-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02147.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.51.2.293"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2006.11.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1079336"},{"key":"e_1_2_6_19_1","first-page":"165","volume-title":"Epilepsy: Etiology, Epidemiology and Prognosis","author":"World Health Organization","year":"2001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527614998.ch5"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.1453","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.1453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:38:32Z","timestamp":1760056712000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.1453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,15]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1002\/bmc.1453"],"URL":"https:\/\/doi.org\/10.1002\/bmc.1453","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2010,11,15]]}}}