{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:22:27Z","timestamp":1790803347324,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The use of blood spot collection cards is a simple way to obtain specimens for therapeutic drug monitoring, assessing adherence to medications and preventing toxicity in a clinical setting. A high\u2010throughput liquid chromatography\u2013electrospray ionization mass spectrometric (LC\u2010ESI\u2010MS) method for determination of rifaximin on dried blood spots (DBS) was developed and validated. It involves solvent extraction of a punch of DBS followed by reversed\u2010phase LC on a monolithic column consisting of a silica rod with bimodal pore structure and detection by ESI\u2010MS. Rifampicin was used as an internal standard (IS). The run time was within 5.0\u2009min with a very low back\u2010pressure at a flow rate of 0.5\u2009mL\/min. The assay was linear from 0.1 to 10\u2009ng\/mL. The mean recovery was 98.42%. The developed method is very simple, rapid and useful for clinical applications. 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