{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:08:48Z","timestamp":1788793728284,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The development and validation of an LC\u2010MS\/MS method for the simultaneous determination of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in human plasma are described. Samples of 200\u2009\u03bcL were extracted with ether\u2013dichloromethane\u2013chloroform (60:30:10, v\/v\/v). The chromatographic separation was performed using a C<jats:sub>18<\/jats:sub> column with methanol\u2013formic acid 20\u2009mmol\/L (70:30) as the mobile phase. The method was linear in a range of 20\u20135000\u2009ng\/mL for albendazole sulfoxide and 10\u20131500\u2009ng\/mL for albendazole sulfone. For both analytes the method was precise (RSD\u2009&lt;\u200912%) and accurate (RE &lt;7%) with high recovery (&gt;90%). The method was successfully applied to determine the plasma and cerebrospinal fluid levels of albendazole sulfoxide and albendazole sulfone in patients with subarachnoidal neurocysticercosis who received albendazole at 30\u2009mg\/kg per day for 7\u2009days. This LC\u2010MS\/MS method yielded a quick, simple and reliable protocol for determining albendazole sulfoxide and albendazole sulfone concentrations in plasma and cerebrospinal fluid samples and is applicable to therapeutic monitoring. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1659","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T04:20:34Z","timestamp":1309494034000},"page":"267-272","source":"Crossref","is-referenced-by-count":21,"title":["A simple LC\u2010MS\/MS method to determine plasma and cerebrospinal fluid levels of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in patients with neurocysticercosis"],"prefix":"10.1002","volume":"26","author":[{"given":"Iliana","family":"Gonz\u00e1lez\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratorio de Neuropsicofarmacolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda  M\u00e9xico D.F. 14269 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Ruiz\u2010Olmedo","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Departamento de Farmacia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico D.F. 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Laboratorio de Infectolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda  M\u00e9xico D.F. 14269 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helgi","family":"Jung\u2010Cook","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuropsicofarmacolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda  M\u00e9xico D.F. 14269 Mexico"},{"name":"Facultad de Qu\u00edmica, Departamento de Farmacia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico D.F. 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570\u20100232(02)00665\u20107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.11.020"},{"key":"e_1_2_6_4_1","first-page":"679","article-title":"Population pharmacokinetics of albendazole in patients with neurocysticercosis","volume":"47","author":"Castro N","year":"2009","journal-title":"International Journal of Clinical Pharmacology and Therapeutics"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.02.022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u2010706x(03)00031\u20107"},{"key":"e_1_2_6_7_1","unstructured":"FDA.Guidance for Industry Bioanalytical Method Validation. 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