{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:53:56Z","timestamp":1760061236306,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A rapid and sensitive LC\u2010MS\/MS method for the quantification of fenofibric acid in rat plasma was developed and validated. Plasma samples were prepared by liquid\u2013liquid extraction with a mixture of <jats:italic>N<\/jats:italic>\u2010hexane\u2013dichloromethane\u2013isopropanol (100:50:5, v\/v\/v). Isocratic chromatographic separation was performed on a reversed\u2010phase Discovery C<jats:sub>18<\/jats:sub> column (2.1\u2009\u00d7\u200950\u2009mm, 5\u2009\u00b5m). The mobile phase was methanol\u2013water\u2013formic (75:25:0.25, v\/v\/v). Detection of fenofibric acid and the internal standard (IS) diclofenac acid was achieved by ESI MS\/MS in the negative ion mode using <jats:italic>m\/z<\/jats:italic> 317\u2009\u2192\u2009<jats:italic>m\/z<\/jats:italic> 213 and <jats:italic>m\/z<\/jats:italic> 294\u2009\u2192\u2009<jats:italic>m\/z<\/jats:italic> 250 transitions, respectively. The method was linear from 0.005 to 1.250\u2009\u00b5g\/mL when 100 \u03bcL plasma was analyzed. The lower limit of quantification was 0.005\u2009\u00b5g\/mL. The intra\u2010 and inter\u2010day precision values were below 8.2%, and accuracy ranged from \u22120.9 to 2.1% in all quality control samples. The recovery was 90.3\u201394.7% and 83.3% for fenofibric acid and IS, respectively. Total run time for each sample analysis was 2.5\u2009min. The validated method was successfully applied to a pharmacokinetic study in six rats after oral administration of fenofibrate, the ester prodrug of fenofibric acid (equivalent to fenofibric acid 5\u2009mg\/kg). The method permits laboratory scientists with access to the appropriate instrumentation to perform rapid fenofibric acid determination. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.1693","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T13:56:32Z","timestamp":1314885392000},"page":"497-501","source":"Crossref","is-referenced-by-count":4,"title":["Development of a sensitive liquid chromatography\/tandem mass spectrometry method for the determination of fenofibric acid in rat plasma"],"prefix":"10.1002","volume":"26","author":[{"given":"Guanxiong","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  27 Taiping Road Beijing 100850 People's Republic of China"},{"name":"Shaanxi University of Chinese Medicine  Century Road Xianyang 712046 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifen","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  27 Taiping Road Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanhua","family":"Meng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  27 Taiping Road Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Song","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine  Century Road Xianyang 712046 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  27 Taiping Road Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  27 Taiping Road Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1002\/bmc.1203"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/S1044-0305(03)00574-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/S0731-7085(98)00051-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1124\/dmd.108.025817"},{"key":"e_1_2_6_6_1","first-page":"50","article-title":"Rapid and simple method for detection of fenofibric acid in human serum by high\u2010performance liquid chromatography","volume":"56","author":"Lossner A","year":"2001","journal-title":"Pharmazie"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1016\/S0026-265X(03)00093-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/S0149-2918(03)80089-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1021\/ac020361s"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1016\/j.chroma.2008.01.060"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1097\/ftd.0b013e318030860a"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1016\/S0378-4347(00)00195-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1016\/j.jpba.2005.05.005"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.1693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.1693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:43:44Z","timestamp":1760046224000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.1693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/bmc.1693"],"URL":"https:\/\/doi.org\/10.1002\/bmc.1693","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}