{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:56:21Z","timestamp":1760061381508,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T00:00:00Z","timestamp":1034294400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A convenient HPLC method to determine phenylpropanolamine (PPA) in addition to phenylephrine (PE) and chlorpheniramine (CPA) in commercially available over\u2010the\u2010counter (OTC) preparations has been developed. Sample solutions were prepared by dilution with water or methanol followed by filtration and direct injection into the HPLC system. The mobile phase was a mixture of methanol\u2013acetonitrile\u2013acetic acid (0.1\u2005<jats:sc>M<\/jats:sc>)\u2013triethylamine (20:20:60:0.6, v\/v\/v\/v) containing sodium heptanesulfonate (0.5\u2005m<jats:sc>M<\/jats:sc>) as an ion pair. The separation was achieved on a reversed\u2010phase ODS column with detection wavelength set at 254\u2005nm. The compounds showed good linearity in the range 2.5\u20131000\u2005\u00b5<jats:sc>M<\/jats:sc> with detection limits ranged from 0.13 to 0.48\u2005\u00b5<jats:sc>M<\/jats:sc>. PE, caffeine and CPA were well separated when present together with PPA. The method was applied to the determination of PPA in pharmaceutical preparations including hard and soft capsules. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.186","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T12:39:51Z","timestamp":1034599191000},"page":"463-469","source":"Crossref","is-referenced-by-count":10,"title":["HPLC determination of phenylpropanolamine in pharmaceutical OTC preparations"],"prefix":"10.1002","volume":"16","author":[{"given":"Kenichiro","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kanehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Kaddoumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600731116"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00599-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600740415"},{"volume-title":"Physicians' Desk Reference","year":"2000","key":"e_1_2_1_5_1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00371-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)01237-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/an9840900619"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00385-X"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:35:33Z","timestamp":1760056533000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/bmc.186"],"URL":"https:\/\/doi.org\/10.1002\/bmc.186","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}