{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:05:14Z","timestamp":1791860714176,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2003,4,4]],"date-time":"2003-04-04T00:00:00Z","timestamp":1049414400000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (\u03b2\u2010adrenergic blockers), econazole, miconazole (anti\u2010fungal agents), cromakalim (anti\u2010hypertensive agent) and etodolac (anti\u2010inflammatory agent) was achieved on cellulose tris (3,5\u2010dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2\u2010propanol at 0.5\u2005mL\/min with detection at 220\u2005nm. The separation factors (\u03b1) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed. Copyright \u00ad\u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.220","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T02:57:19Z","timestamp":1106189839000},"page":"113-117","source":"Crossref","is-referenced-by-count":108,"title":["Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5\u2010dichlorophenylcarbamate) chiral stationary phase"],"prefix":"10.1002","volume":"17","author":[{"given":"Imran","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Y.","family":"Aboul\u2010Enein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160100884"},{"key":"e_1_2_1_3_1","volume-title":"The Impact of Stereochemistry on Drug Development and Use","author":"Aboul\u2010Enein HY","year":"1997"},{"key":"e_1_2_1_4_1","volume-title":"Chromatographic Enantioseparation: Methods and Applications","author":"Allenmark S","year":"1991"},{"key":"e_1_2_1_5_1","volume-title":"Chiral Chromatography","author":"Beesley TE","year":"1998"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207003331391"},{"key":"e_1_2_1_7_1","volume-title":"Statements for the Development of New Stereoisomeric Drugs","author":"FDA Policy","year":"1992"},{"key":"e_1_2_1_8_1","volume-title":"Chiral Separations by HPLC","author":"Krstulovic AM","year":"1989"},{"key":"e_1_2_1_9_1","volume-title":"Chiral Separations by HPLC: Applications to Pharmaceutical Compounds","author":"Krstulovic AM","year":"1989"},{"key":"e_1_2_1_10_1","first-page":"731","volume-title":"Macromolecular Design of Polymeric Materials","author":"Okamoto Y","year":"1997"},{"key":"e_1_2_1_11_1","first-page":"336","volume-title":"Chiral Separations by HPLC: Applications to Pharmaceutical Compounds","author":"Shibata T","year":"1989"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6634-2"},{"key":"e_1_2_1_13_1","volume-title":"Practical Approach to Chiral Separations by Liquid Chromatography","author":"Subramanian GA","year":"1994"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)90318-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)93965-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.72.1815"},{"key":"e_1_2_1_17_1","volume-title":"Chromatographic Chiral Separations","author":"Zief M","year":"1988"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:09:46Z","timestamp":1760044186000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":16,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1002\/bmc.220"],"URL":"https:\/\/doi.org\/10.1002\/bmc.220","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}