{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:33:40Z","timestamp":1770435220618,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A sensitive, rapid and selective ultra\u2010performance liquid chromatography\u2013tandem mass spectrometric (UPLC\u2010MS\/MS) method was developed for the determination and pharmacokinetic study of domperidone in human plasma. Diphenhydramine was used as the internal standard. Plasma sample pretreatment involved a one\u2010step liquid\u2013liquid extraction with a mixture of diethyl ether\u2013dichloromethane (3:2, v\/v). The analysis was carried out on an Acquity UPLC<jats:sup>TM<\/jats:sup> BEH C<jats:sub>18<\/jats:sub> column. The mobile phase consisted of methanol\u2013water containing 10 mmol\/L ammonium acetate and 0.5% (v\/v) formic acid (60:40, v\/v). The detection was performed on a triple quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionizationsource with positive mode. Each plasma sample was chromatographed within 2.1 min. The standard curves for domperidone were linear (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009\u2265\u20090.99) over the concentration range of 0.030\u201331.5 ng\/mL with a lower limit of quantification of 0.030 ng\/mL. The intra\u2010 and inter\u2010day precision (relative standard deviation) values were not higher than 13% and accuracy (relative error) was from \u22127.6 to 1.2% at three quality control levels. The method herein described was superior to previous methods and was successfully applied to the pharmacokinetic study of domperidone in healthy Chinese volunteers after oral administration. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.2801","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:03:40Z","timestamp":1344989020000},"page":"371-376","source":"Crossref","is-referenced-by-count":6,"title":["Development and validation of UPLC\u2010MS\/MS method for determination of domperidone in human plasma and its pharmacokinetic application"],"prefix":"10.1002","volume":"27","author":[{"given":"Xintao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Famei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhili","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy Shenyang Pharmaceutical University  Wenhua Road 103# Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337\u2010009\u20101032\u20100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198224050-00002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0535-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189516"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/47.10.881"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.02.044"},{"key":"e_1_2_7_8_1","first-page":"1230","article-title":"A double\u2010blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis","volume":"94","author":"Patterson D","year":"1999","journal-title":"The American Journal of Gastroenterology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01553-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120618"},{"key":"e_1_2_7_11_1","unstructured":"US Food and Drug Administration Center for Drug Evaluation and Research.Guidance for Industry: Bioanalytical Method Validation May2001. 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