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Pharmacokinetic comparison was conducted by allocating mice into two groups; an ABS group (intravenous study and oral studies, <jats:italic>n<\/jats:italic>\u2009=\u20095 each) and a manual group (intravenous and oral studies; <jats:italic>n<\/jats:italic>\u2009=\u20095 each). Significant differences in pharmacokinetic parameters (area under the curve and clearances) were observed between ABS and manual groups. This could be mainly due to the blood sampling site difference (via heart puncture in traditional manual group and via carotid artery in ABS groups). The low <jats:italic>F<\/jats:italic> of isoLQ could be mainly due to a considerable gastrointestinal and\/or hepatic first\u2010pass effect and not to incomplete absorption. The driving force for distribution and elimination of drugs is its concentration in the arterial blood. Therefore, the ABS method was found to be a useful drug development tool for accelerating the process of preclinical <jats:italic>in vivo<\/jats:italic> studies and for obtaining reliable and accurate pharmacokinetic parameters in mice. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.2854","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T23:47:00Z","timestamp":1358812020000},"page":"741-749","source":"Crossref","is-referenced-by-count":17,"title":["A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing\/blood sampling system"],"prefix":"10.1002","volume":"27","author":[{"given":"Seung Yon","family":"Han","sequence":"first","affiliation":[{"name":"College of Pharmacy Dongguk University\u2010Seoul  32 Dongguk\u2010lo, Ilsandong\u2010gu Goyang Gyeonggi\u2010do 410\u2010820 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Won","family":"Chin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dongguk University\u2010Seoul  32 Dongguk\u2010lo, Ilsandong\u2010gu Goyang Gyeonggi\u2010do 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