{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:36:36Z","timestamp":1773048996839,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The effects of organic modifier and temperature on the enantioseparation of 10 triazoles and eight imidazoles, using supercritical fluid chromatography with the Chiralpak AD column, have been investigated in this work. For this purpose four different organic modifiers (methanol, ethanol, 2\u2010propanol and acetonitrile) were evaluated. Only in the case of two compounds could the enantiomeric separation not be achieved with any of the modifiers tested; the rest of compounds were baseline or partially resolved with at least one of the modifiers. The alcohol\u2010type modifiers provided the best results in terms of retention time and resolution. In general, retention increased in the order methanol\u2009&lt;\u2009ethanol\u2009&lt;\u20092\u2010propanol; moreover it was possible to establish a relationship between the retention and the number of aromatic rings and dioxolane groups in the molecule, that is, the higher the number is, the higher the retention time. From the study of the temperature effect, the enthalpy\u2013entropy compensation was demonstrated for all the compounds, except for bifonazole using methanol and miconazole using acetonitrile. This suggested that both analytes are enantiomerically resolved through different mechanisms. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3013","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T05:36:41Z","timestamp":1377581801000},"page":"152-158","source":"Crossref","is-referenced-by-count":35,"title":["Effects of organic modifier and temperature on the enantiomeric separation of several azole drugs using supercritical fluid chromatography and the Chiralpak AD column"],"prefix":"10.1002","volume":"28","author":[{"given":"L.","family":"Toribio","sequence":"first","affiliation":[{"name":"I.U. CINQUIMA, Analytical Chemistry Group University of Valladolid  E\u201047011 Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Bernal","sequence":"additional","affiliation":[{"name":"I.U. CINQUIMA, Analytical Chemistry Group University of Valladolid  E\u201047011 Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"I.U. CINQUIMA, Analytical Chemistry Group University of Valladolid  E\u201047011 Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bernal","sequence":"additional","affiliation":[{"name":"I.U. CINQUIMA, Analytical Chemistry Group University of Valladolid  E\u201047011 Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"del Nozal","sequence":"additional","affiliation":[{"name":"I.U. CINQUIMA, Analytical Chemistry Group University of Valladolid  E\u201047011 Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-022X(00)00060-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00637-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10100"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.01.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01920-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200301591"},{"issue":"8","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/jm00194a023","article-title":"Antimycotic imidazoles. Part 4. 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