{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:19:19Z","timestamp":1774585159414,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The combination of certain non\u2010sedating antihistamines (NSA) such as fexofenadine (FXD), ketotifen (KET) and loratadine (LOR) with pseudoephedrine (PSE) or acetaminophen (ACE) is widely used in the treatment of allergic rhinitis, conjunctivitis and chronic urticaria. A rapid, simple, selective and precise densitometric method was developed and validated for simultaneous estimation of six synthetic binary mixtures and their pharmaceutical dosage forms. The method employed thin layer chromatography aluminum plates precoated with silica gel G 60\u2009F<jats:sub>254<\/jats:sub> as the stationary phase. The mobile phases chosen for development gave compact bands for the mixtures FXD\u2013PSE (I), KET\u2013PSE (II), LOR\u2013PSE (III), FXD\u2013ACE (IV), KET\u2013ACE (V) and LOR\u2013ACE (VI) [Retardation factor (<jats:italic>R<\/jats:italic><jats:sub>f<\/jats:sub>) values were (0.20, 0.32), (0.69, 0.34), (0.79, 0.13), (0.36, 0.70), (0.51, 0.30) and (0.76, 0.26), respectively]. Spectrodensitometric scanning integration was performed at 217, 218, 218, 233, 272 and 251\u2009nm for the mixtures I\u2013VI, respectively. The linear regression data for the calibration plots showed an excellent linear relationship. The method was validated for precision, accuracy, robustness and recovery. Limits of detection and quantitation were calculated. Statistical analysis proved that the method is reproducible and selective for the simultaneous estimation of these binary mixtures. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3033","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:39:42Z","timestamp":1381527582000},"page":"391-400","source":"Crossref","is-referenced-by-count":20,"title":["Thin layer chromatography\u2013densitometric determination of some non\u2010sedating antihistamines in combination with pseudoephedrine or acetaminophen in synthetic mixtures and in pharmaceutical formulations"],"prefix":"10.1002","volume":"28","author":[{"given":"Michael E.","family":"El\u2010Kommos","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University  Assiut 71526 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia M.","family":"El\u2010Gizawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University  Assiut 71526 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha N.","family":"Atia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University  Assiut 71526 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha M.","family":"Hosny","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University  Assiut 71526 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms125"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1556\/JPC.26.2013.1.11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422012001000012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2010.06.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0526-5"},{"key":"e_1_2_6_7_1","first-page":"850","volume-title":"British Pharmacopoeia","year":"2009"},{"issue":"13","key":"e_1_2_6_8_1","first-page":"23","article-title":"Determination of ketotifen fumarate nasal drops by RP\u2010HPLC","volume":"9","author":"Chen J","year":"2011","journal-title":"China Pharmaceuticals"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/AChrom.24.2012.3.10"},{"issue":"1","key":"e_1_2_6_10_1","first-page":"135","article-title":"Spectrophotometric multicomponent analysis of a mixture of triprolidine hydrochloride and pseudoephedrine hydrochloride in pharmaceutical formulations by partial least\u2010squares multivariate calibration","volume":"52","author":"Donmez OA","year":"2007","journal-title":"Chemia Analityczna (Warsaw, Poland)"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1556\/JPC.25.2012.2.13"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00664-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/209518"},{"key":"e_1_2_6_14_1","first-page":"1888","volume-title":"European Pharmacopoeia","year":"2007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms082"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ay05679h"},{"key":"e_1_2_6_17_1","unstructured":"ICH.Harmonized Tripartite Guideline: Validation of Analytical Procedures: Text and Methodology Q2 (R1). 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