{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:41:52Z","timestamp":1793014912190,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373924"],"award-info":[{"award-number":["81373924"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Huo Luo Xiao Ling Dan (HLXLD), a Chinese herbal formula composed of 11 different herbs, has been used traditionally for the treatment of arthritis and other chronic inflammatory diseases. However, the pharmacokinetic profile of its anti\u2010inflammatory bioactive compounds has not been elucidated. Boswellic acids are the bioactive compounds with potent anti\u2010inflammatory activity isolated from <jats:italic>Boswellia serrate<\/jats:italic> which is one of the 11 herbs of HLXLD. The objective of the study was to compare the pharmacokinetics of the two bioactive bowsellic acids: 11\u2010keto\u2010<jats:italic>\u03b2<\/jats:italic>\u2010boswellic acid and 3\u2010<jats:italic>O<\/jats:italic>\u2010acetyl\u201011\u2010keto\u2010<jats:italic>\u03b2<\/jats:italic>\u2010boswellic following oral administration of HLXLD or <jats:italic>Boswellia serrata<\/jats:italic> extract alone in normal and arthritic rats. An LC\u2010MS method was developed and validated for the determination of 11\u2010keto\u2010<jats:italic>\u03b2<\/jats:italic>\u2010boswellic acid and 3\u2010<jats:italic>O<\/jats:italic>\u2010acetyl\u201011\u2010keto\u2010<jats:italic>\u03b2<\/jats:italic>\u2010boswellic in the comparative pharmacokinetic study. The results showed that there were significant differences in pharmacokinetic parameters between normal and arthritic groups. Interestingly, the absorptions of two boswellic acids were significantly higher in HLXLD than <jats:italic>Boswellia serrata<\/jats:italic> extract alone, indicating the synergistic effect of other herbal ingredients in HLXLD. This comparative pharmacokinetic study provided direct evidence supporting the notion that the efficacy of a complex mixture such as HLXLD is better than that of single components in treating human diseases. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3182","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T05:11:10Z","timestamp":1399525870000},"page":"1402-1408","source":"Crossref","is-referenced-by-count":33,"title":["Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of <i>Boswellia serrata<\/i> extract or Huo Luo Xiao Ling Dan by LC\u2010MS"],"prefix":"10.1002","volume":"28","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenning","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shenyang Pharmaceutical University  Shenyang 110016 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