{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:49:13Z","timestamp":1791287353517,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A simple and sensitive gas chromatography\u2013electron ionization\u2013mass spectrometry (GC\u2010EI\u2010MS) method using dried plasma spot testing cards was developed for determination of valproic acid and gabapentin concentrations in human plasma from patients receiving in\u2010home medical care. We have proposed that a simple, easy and dry sampling method is suitable for in\u2010home medical patients for therapeutic drug monitoring. Therefore, in the present study, we used recently developed commercially available easy handling cards: Whatman FTA DMPK\u2010A and Bond Elut DMS. In\u2010home medical care patients can collect plasma using these simple kits. The spots of plasma on the cards were extracted into methanol and then evaporated to dryness. The residues were trimethylsilylated using <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2010trimethylsilyltrifluoroacetamide. For GC\u2010EI\u2010MS analysis, the calibration curves on both cards were linear from 10 to 200\u2009\u00b5g\/mL for valproic acid, and from 0.5 to 10\u2009\u00b5g\/mL for gabapentin. Intra\u2010 and interday precisions in plasma were both \u226413.0% (coefficient of variation), and the accuracy was between 87.9 and 112% for both cards within the calibration curves. The limits of quantification were 10\u2009\u00b5g\/mL for valproic acid and 0.5\u2009\u00b5g\/mL for gabapentin on both cards. We believe that the present method will be useful for in\u2010home medical care. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3217","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T08:12:28Z","timestamp":1401696748000},"page":"1756-1762","source":"Crossref","is-referenced-by-count":20,"title":["Gas chromatography\u2013electron ionization\u2013mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in\u2010home medical care"],"prefix":"10.1002","volume":"28","author":[{"given":"Kayo","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacotherapy Hiroshima University  Kasumi 1\u20102\u20103, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuro","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacotherapy Hiroshima University  Kasumi 1\u20102\u20103, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Yokoshige","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacotherapy Hiroshima University  Kasumi 1\u20102\u20103, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacotherapy Hiroshima University  Kasumi 1\u20102\u20103, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacotherapy Hiroshima University  Kasumi 1\u20102\u20103, Minami\u2010ku Hiroshima 734\u20108551 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.06.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31819e91ce"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00755-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1539\/sangyoeisei.49.89"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2011.07.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-4048-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1708-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/31.9.555"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200012000-00011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.02.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2726"},{"key":"e_1_2_7_13_1","first-page":"725","article-title":"Research study on the feasibility of testing for detection of life\u2010style related diseases by a self\u2010blood collection kit at pharmacies","volume":"36","author":"Shimizu N","year":"2009","journal-title":"Clinical Evaluation"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac8022839"},{"key":"e_1_2_7_15_1","unstructured":"US DHHS FDAandCDER.Guidance for Industry: Bionalytical Method Validation. 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