{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:43:36Z","timestamp":1788871416629,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Ministry of Science Education","award":["Research Project CTQ2010-20554"],"award-info":[{"award-number":["Research Project CTQ2010-20554"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A dispersive liquid\u2013liquid micellar microextraction (DLLMME) method coupled with ultra\u2010high\u2010performance liquid chromatography (UHPLC) using Diode Array Detector (DAD) detector was developed for the analysis of five pharmaceutical compounds of different nature in wastewaters. A micellar solution of a surfactant, polidocanol, as extraction solvent (100\u2009\u03bcL) and chloroform as dispersive solvent (200\u2009\u03bcL) were used to extract and preconcentrate the target analytes. Samples were heated above critical temperature and the cloudy solution was centrifuged. After removing the chloroform, the reduced volume of surfactant was then injected in the UHPLC system. In order to obtain high extraction efficiency, the parameters affecting the liquid\u2010phase microextraction, such as time and temperature extraction, ionic strength and surfactant and organic solvent volume, were optimized using an experimental design. Under the optimized conditions, this procedure allows enrichment factors of up to 47\u2010fold. The detection limit of the method ranged from 0.1 to 2.0\u2009\u00b5g\/L for the different pharmaceuticals. Relative standard deviations were &lt;26% for all compounds. The procedure was applied to samples from final effluent collected from wastewater treatment plants in Las Palmas de Gran Canaria (Spain), and two compounds were measured at 67 and 113\u2009\u00b5g\/L in one of them. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3282","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T02:30:05Z","timestamp":1406169005000},"page":"353-356","source":"Crossref","is-referenced-by-count":8,"title":["A dispersive liquid\u2013liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra\u2010high\u2010performace liquid chromatography with DAD detection"],"prefix":"10.1002","volume":"29","author":[{"given":"Sarah","family":"Montesdeoca\u2010Esponda","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidad de Las Palmas de G.C.  35017 Las Palmas de G.C. Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mahugo\u2010Santana","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidad de Las Palmas de G.C.  35017 Las Palmas de G.C. Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoraida","family":"Sosa\u2010Ferrera","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidad de Las Palmas de G.C.  35017 Las Palmas de G.C. Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Juan","family":"Santana\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidad de Las Palmas de G.C.  35017 Las Palmas de G.C. Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0394-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2010.03.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.10.089"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-09259-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960145h"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/B202092K"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2011.01.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(02)00762-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.03.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.11.088"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2003.12.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2009.10.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9009963"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.3282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:01:06Z","timestamp":1760058066000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.3282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,24]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/bmc.3282"],"URL":"https:\/\/doi.org\/10.1002\/bmc.3282","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,24]]}}}