{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:25:16Z","timestamp":1774956316069,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A high\u2010performance liquid chromatography with ultraviolet detection method has been developed for the simultaneous determination of a set of reliable markers of renal function, including creatinine, uric acid, kynurenine and tryptophan in plasma. Separation was achieved by an Agilent HC\u2010C<jats:sub>18<\/jats:sub> (2) analytical column. Gradient elution and programmed wavelength detection allowed the method to be used to analyze these compounds by just one injection. The total run time was 25\u2009min with all peaks of interest being eluted within 13\u2009min. Good linear responses were found with correlation coefficient &gt;0.999 for all analytes within the concentration range of the relevant levels. The recovery was: creatinine, 101 \u00b1 1%; uric acid, 94.9 \u00b1 3.7%; kynurenine, 100 \u00b1 2%; and tryptophan, 92.6 \u00b1 2.9%. Coefficients of variation within\u2010run and between\u2010run of all analytes were \u22642.4%. The limit of detection of the method was: creatinine, 0.1\u2009\u00b5mol\/L; uric acid, 0.05\u2009\u00b5mol\/L; kynurenine, 0.02\u2009\u00b5mol\/L; and tryptophan, 1\u2009\u00b5mol\/L. The developed method could be employed as a useful tool for the detection of chronic kidney disease, even at an early stage. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3291","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T02:35:52Z","timestamp":1404959752000},"page":"410-415","source":"Crossref","is-referenced-by-count":42,"title":["Simultaneous determination of plasma creatinine, uric acid, kynurenine and tryptophan by high\u2010performance liquid chromatography: method validation and in application to the assessment of renal function"],"prefix":"10.1002","volume":"29","author":[{"given":"Jianxing","family":"Zhao","sequence":"first","affiliation":[{"name":"Ruijin Hospital Shanghai Jiao Tong University School of Medicine and Shanghai Institute of Hypertension  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00109.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.01.019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9280"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00341-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90478-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1525"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04440.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeu.12080"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.05.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129031"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.3.579"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm051"},{"key":"e_1_2_7_14_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2778"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.10.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/bmc.1690","article-title":"Simultaneous determination of simvastatin, lovastatin and niacin in human plasma by LC\u2010MS\/MS and its application to a human pharmacokinetic study","volume":"26","author":"Pilli NR","year":"2012","journal-title":"Biomedical Chromatography"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2715"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F565"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn739"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)01218-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200403000-00004"},{"key":"e_1_2_7_23_1","volume-title":"Guidance for Industry, Bioanalytical Method Evaluation","author":"US Food and Drug Administration, Center for Drug Evaluation and Research","year":"2001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.445"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0801(199803\/04)12:2<47::AID-BMC717>3.0.CO;2-Y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3192"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.04.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.790301"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ay41061g"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.03.033"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.01.006"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.07.035"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/clinchem\/31.1.109","article-title":"Simultaneous determination of uric acid and creatinine in plasma by reversed\u2010phase liquid chromatography","volume":"31","author":"Zhiri A","year":"1985","journal-title":"Clinical Chemistry"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.3291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:00:49Z","timestamp":1760058049000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.3291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/bmc.3291"],"URL":"https:\/\/doi.org\/10.1002\/bmc.3291","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]}}}