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Sample preparation was performed by one\u2010step protein precipitation with methanol. The analytes were chromatographed on a reversed\u2010phase YMC\u2010ODS\u2010AQ C<jats:sub>18<\/jats:sub> Column (2.0 \u00d7 100 mm,3 \u00b5m) by a gradient program at a flow rate of 0.30 mL\/min. Quantification was performed on a triple quadrupole tandem mass spectrometer via electrospray ionization in positive ion mode. The method was validated for selectivity, linearity, accuracy, precision, matrix effect, recovery and stability. The calibration curve was linear over the concentration range 0.2\u2013120 ng\/mL for OLZ and 0.5\u201350 ng\/mL for DMO. Intra\u2010 and interday precisions for OLZ and DMO were &lt;11.29%, and the accuracy ranged from 95.23 to 113.16%. The developed method was subsequently applied to therapeutic drug monitoring for psychiatric patients receiving therapy of OLZ tablets. The method seems to be suitable for therapeutic drug monitoring of patients undergoing therapy with OLZ and might contribute to prediction of the risk of adverse reactions. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3329","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T22:42:15Z","timestamp":1412808135000},"page":"671-678","source":"Crossref","is-referenced-by-count":13,"title":["Simultaneous quantification of olanzapine and its metabolite <i>N<\/i>\u2010desmethylolanzapine in human plasma by liquid chromatography tandem mass spectrometry for therapeutic drug monitoring"],"prefix":"10.1002","volume":"29","author":[{"given":"Hong\u2010gang","family":"Lou","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, 2nd Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zou\u2010rong","family":"Ruan","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, 2nd Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou 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