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For this purpose four different polysaccharide based chiral stationary phases were evaluated, namely Chiralcel OD\u2010H (cellulose <jats:italic>tris<\/jats:italic>\u20103,5\u2010dimethylphenylcarbamate), Chiralcel OJ (cellulose <jats:italic>tris<\/jats:italic>\u2010methylbenzoate), Chiralpak AD (amylose <jats:italic>tris<\/jats:italic>\u20103,5\u2010dimethylphenylcarbamate) and Chiralpak AS (amylose <jats:italic>tris<\/jats:italic>\u2010(<jats:italic>S<\/jats:italic>)\u20101\u2010phenylethylcarbamate) with different alcoholic modifiers on different amounts in <jats:italic>n<\/jats:italic>\u2010heptane. A temperature study was carried out, between 20 and 40\u2009\u00b0C and the apparent thermodynamic parameters were calculated thanks to the Van't Hoff linearization. For all compounds (except 3), \u0394\u0394<jats:italic>H\u00b0<\/jats:italic> and \u0394\u0394<jats:italic>S\u00b0<\/jats:italic> exhibited positive values ranging from 791.2 to 9999.3\u2009J\/mol and from 3.9 to 37.8\u2009J\/K\/mol respectively, indicating entropically driven separations. Optimized conditions led to goof resolution of 2.37 for compound 1 on Chiralpak AS, with heptane\u20132\u2010propanol 90:10 (v\/v), at a temperature of 30\u2009\u00b0C. Then they were transposed to the preparative scale for compound 1, generating 22\u2009mg of each enantiomer with an 80% yield. The limits of detection and of quantification were determined to allow the calculation of the enantiomeric excess. They were found with very low values, equal to 0.32 and 1.05\u2009\u00b5 <jats:sc>m<\/jats:sc> and 0.33 and 1.11\u2009\u00b5 <jats:sc>m,<\/jats:sc> respectively, for peaks 1 and 2 of compound 1. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3332","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T04:50:11Z","timestamp":1412139011000},"page":"689-697","source":"Crossref","is-referenced-by-count":3,"title":["Enantioseparation and thermodynamic study of naphthalene derivatives, new melatoninergic agonists, on coated amylose [<i>tris<\/i>(<i>S<\/i>)\u20101\u2010phenylethylcarbamate] stationary phase. Transposition to preparative scale"],"prefix":"10.1002","volume":"29","author":[{"given":"Elodie","family":"Landagaray","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lille Nord de France UDSL, EA 4481 and EA GRIIOT, UFR Pharmacie  F\u201059000 Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00efd","family":"Yous","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille Nord de France UDSL, EA 4481 and EA GRIIOT, UFR Pharmacie  F\u201059000 Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Vaccher","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille Nord de France UDSL, EA 4481 and EA GRIIOT, UFR Pharmacie  F\u201059000 Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Lipka","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille Nord de France UDSL, EA 4481 and EA GRIIOT, UFR Pharmacie  F\u201059000 Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.220"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.12.066"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-006-0159-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.033"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)00729-S"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00648-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.027"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300294"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00951-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.02.038"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.07.043"},{"key":"e_1_2_6_13_1","unstructured":"ICH.Q2B Validation of Analytical Procedures: Methodology. 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