{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:54:15Z","timestamp":1760061255705,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T00:00:00Z","timestamp":1421971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","award":["No.2008ZX09305-003 and No. 2010ZXJ0900X-005"],"award-info":[{"award-number":["No.2008ZX09305-003 and No. 2010ZXJ0900X-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meditinib (ME) is a novel tyrosine kinase inhibitor used as an antichronic myeloid leukemia drug. A simple, sensitive and specific LC\/MS\/MS method was developed and validated for the analysis of ME and its metabolite demethylation meditinib (PI) in monkey plasma using naltrexone as the internal standard. Sample preparation involved protein precipitation with methanol. The analysis was carried out on an Agilent C<jats:sub>8<\/jats:sub> column (3.5\u2009\u00b5m, 2.1\u2009\u00d7\u200950\u2009mm). Elution was achieved with a mobile phase gradient varying the proportion of a water solution containing 0.1% formic acid (solvent A) and a 0.1% formic acid in methanol solution (solvent B) at a flow rate of 300\u2009\u03bcL\/min. The method had a linear calibration curve over the concentration range of 2\u20131000\u2009ng\/mL for ME and 2\u20131000\u2009ng\/mL for PI. The lower limits of quantification of ME and PI were 2 and 2\u2009ng\/mL, respectively. The intra\u2010 and inter\u2010day precision values were &lt;15% and accuracy values were within \u00b110.0%. The mean recoveries of ME and PI from plasma were &gt;85%. The assay has been successfully used for pharmacokinetic evaluation of ME and PI using the monkey as an animal model, and those data are reported for the first time. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3415","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T04:02:01Z","timestamp":1421985721000},"page":"1259-1266","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous determination of the novel tyrosine kinase inhibitor meditinib and its active metabolite demethylation meditinib in monkey plasma by liquid chromatography\u2013tandem mass spectrometry and its application to pharmacokinetic studies"],"prefix":"10.1002","volume":"29","author":[{"given":"Feng","family":"Liang","sequence":"first","affiliation":[{"name":"National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Pharmacology and Toxicology Academy of Military Medical Sciences  27 Taiping Road, Haidian District Beijing 100850 People's Republic of China"},{"name":"Pharmacy Department of 371 Hospital  210 Wenhua Road, Hongqi District Xinxiang City Henan Province 453000 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Kong","sequence":"additional","affiliation":[{"name":"National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Pharmacology and Toxicology Academy of Military Medical Sciences  27 Taiping Road, Haidian District Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Gloria Pharmaceuticals Co., Ltd  No.28 Building, Ronghui Garden, Yuhua Road, Konggang Airport Development Zone B, Shunyi District Beijing 101318 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Gloria Pharmaceuticals Co., Ltd  No.28 Building, Ronghui Garden, Yuhua Road, Konggang Airport Development Zone B, Shunyi District Beijing 101318 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejie","family":"Sun","sequence":"additional","affiliation":[{"name":"Gloria Pharmaceuticals Co., Ltd  No.28 Building, Ronghui Garden, Yuhua Road, Konggang Airport Development Zone B, Shunyi District Beijing 101318 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Liu","sequence":"additional","affiliation":[{"name":"Gloria Pharmaceuticals Co., Ltd  No.28 Building, Ronghui Garden, Yuhua Road, Konggang Airport Development Zone B, Shunyi District Beijing 101318 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinling","family":"Cai","sequence":"additional","affiliation":[{"name":"Gloria Pharmaceuticals Co., Ltd  No.28 Building, Ronghui Garden, Yuhua Road, Konggang Airport Development Zone B, Shunyi District Beijing 101318 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbiao","family":"Guan","sequence":"additional","affiliation":[{"name":"National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Pharmacology and Toxicology Academy of Military Medical Sciences  27 Taiping Road, Haidian District Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigao","family":"Ding","sequence":"additional","affiliation":[{"name":"National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Pharmacology and Toxicology Academy of Military Medical Sciences  27 Taiping Road, Haidian District Beijing 100850 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-561"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441402"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410306"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002315"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-015347"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401706"},{"key":"e_1_2_7_9_1","first-page":"49","article-title":"Staging and prognosis in chronic myelogenous leukemia","volume":"25","author":"Sokal JE","year":"1988","journal-title":"Seminars in Hematology"}],"container-title":["Biomedical 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