{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:17Z","timestamp":1786977137222,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202920"],"award-info":[{"award-number":["81202920"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373946"],"award-info":[{"award-number":["81373946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81303221"],"award-info":[{"award-number":["81303221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dioscin (DIS), one of the most abundant bioactive steroidal saponins in\n                    <jats:italic>Dioscorea<\/jats:italic>\n                    sp., is used as a complementary medicine to treat coronary disease and angina pectoris in China. Although the pharmacological activities and pharmacokinetics of DIS have been well demonstrated, information regarding the final metabolic fates is very limited. This study investigated the\n                    <jats:italic>in vivo<\/jats:italic>\n                    metabolic profiles of DIS after oral administration by ultra\u2010performance liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry method. The structures of the metabolites were identified and tentatively characterized by means of comparing the molecular mass, retention time and fragmentation pattern of the analytes with those of the parent compound. A total of eight metabolites, including seven phase I and one phase II metabolites, were detected and tentatively identified for the first time. Oxidation, deglycosylation and glucuronidation were found to be the major metabolic processes of the compound in rats. In addition, a possible metabolic pathway on the biotransformation of DIS\n                    <jats:italic>in vivo<\/jats:italic>\n                    was proposed. This study provides valuable and new information on the metabolism of DIS, which will be helpful for further understanding its mechanism of action. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/bmc.3439","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T14:29:05Z","timestamp":1423751345000},"page":"1415-1421","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic profiles of dioscin in rats revealed by ultra\u2010performance liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"29","author":[{"given":"He","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Di","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine  Nanjing 210046 People's Republic of China"},{"name":"Department of Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences  Nanjing 210028 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.01.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007782109788"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2004.11.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.988"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.690"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2007.07.070"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2820"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3630"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1336521"},{"key":"e_1_2_7_11_1","first-page":"47","article-title":"Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells","volume":"64","author":"Qin J","year":"2014","journal-title":"Arzneimittelforschung Drug Research"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.13.3.18693"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.February.28.6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.037044"},{"key":"e_1_2_7_15_1","first-page":"79","article-title":"Advance in Dioscin and its hydrolysate in treating cardiovasular disease","volume":"43","author":"Zhang N","year":"2009","journal-title":"Shanghai Journal of Traditional Chinese Medicine"},{"key":"e_1_2_7_16_1","first-page":"159","article-title":"Systematic evaluation of Shuyu Zaogan tablets for coronary heart disease","volume":"32","author":"Zhang ZH","year":"2011","journal-title":"World Clinical Drugs"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3439","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.3439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:09:41Z","timestamp":1760047781000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.3439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,10]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/bmc.3439"],"URL":"https:\/\/doi.org\/10.1002\/bmc.3439","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,10]]}}}