{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:24:54Z","timestamp":1760887494909,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T00:00:00Z","timestamp":1088726400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A capillary electrochromatographic (CEC) method was applied to the simultaneous separation of barbiturates (barbital, phenobarbital, secobarbital and thiopental) and benzodiazepines (nitrazepam, diazepam and triazolam). The separation was performed in a 75 \u00b5m i.d. capillary, packed with 3\u2010(1,8\u2010naphthalimido)propyl\u2010modi\ufb01ed silyl silica gel (NAIP), studying the effects of buffer pH and mobile phase composition. Using an applied voltage of 20 kV and the short\u2010end injection method (9 cm capillary effective length), the mobile phase of 1.0 m<jats:sc>m<\/jats:sc> citrate buffer (pH 5.0) containing 45% methanol provided the baseline separation of seven toxic drugs in less than 9 min. In CEC with NAIP, the benzodiazepines were separated by the combination of hydrophobic and <jats:italic>\u03c0<\/jats:italic>\u2013<jats:italic>\u03c0<\/jats:italic> interactions, whereas the separation of the barbiturates was based on the hydrophobic interaction. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.346","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T06:01:47Z","timestamp":1088748107000},"page":"396-399","source":"Crossref","is-referenced-by-count":13,"title":["Rapid separation of barbiturates and benzodiazepines by capillary electrochromatography with 3\u2010(1,8\u2010naphthalimido)propyl\u2010modi\ufb01ed silyl silica gel"],"prefix":"10.1002","volume":"18","author":[{"given":"Kaname","family":"Ohyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Fujishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.42.12_817"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02290365"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00386-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/5.4.177"},{"key":"e_1_2_1_6_1","first-page":"228","volume":"24","author":"Kuroda N","year":"1995","journal-title":"Japanese Journal of Clinical Chemistry"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826079608015115"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00428-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1081\/JLC-100100507"},{"journal-title":"Electrophoresis","article-title":"Capillary electrochromatography of caffeine and its metabolites in rat brain using microdialysis technique","author":"Ohyama K","key":"e_1_2_1_10_1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/26.7.500"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00318-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.8.726"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00089-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(96)02081-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00117-4"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T23:31:18Z","timestamp":1760052678000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/bmc.346"],"URL":"https:\/\/doi.org\/10.1002\/bmc.346","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}