{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:18:48Z","timestamp":1792091928181,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The lipophilicity (R<jats:sub>M0<\/jats:sub>) and specific hydrophobic surface area for the representatives of four generation cephalosporins have been determined by reversed\u2010phase thin\u2010layer chromatography, and the effect of different mobile\u2010phase modifiers (such as methanol, acetonitrile, acetone, 1,4\u2010dioxane and 2\u2010propanol) on the retention has been studied. The compounds studied showed typical retention behavior; their R<jats:sub>M<\/jats:sub> values decreased linearly with increasing concentration of the organic modifier in the eluent. The linear correlations between the volume fraction of the organic solvent and the R<jats:sub>M<\/jats:sub> values over a limited range were established for each solute, resulting in high values of correlation coefficients (&gt;0.95 in most cases). R<jats:sub>M<\/jats:sub> values were determined by various concentrations of organic modifier, and the correlation obtained was extrapolated to 0% of organic modifier. Chromatographically established logP (R<jats:sub>M0<\/jats:sub>) parameters were compared with computationally calculated partition coefficients values (AClogP, ALOGP, KOWWIN, ALOGPs, XLOGP2, MLOGP and XLOGP3) and experimental octanol\u2013water logP values (measured by the shake flask method). The received results demonstrate that RP\u2010TLC may be a good alternative technique for analytics in describing the lipophilic nature of investigated cephalosporins as well as the activity. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3490","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T03:29:10Z","timestamp":1432092550000},"page":"1759-1768","source":"Crossref","is-referenced-by-count":21,"title":["Lipophilicity study of eight cephalosporins by reversed\u2010phase thin\u2010layer chromatographic method"],"prefix":"10.1002","volume":"29","author":[{"given":"Monika","family":"D\u0105browska","sequence":"first","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry Faculty of Pharmacy Collegium Medicum Jagiellonian University  9 Medyczna Str 30\u2010688 Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Komsta","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry Medical University of Lublin  4 Jaczewskiego Str 20\u2010090 Lublin 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