{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:24:00Z","timestamp":1790393040801,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Planning Project of Heilongjiang Province","award":["no. GC12C305-5"],"award-info":[{"award-number":["no. GC12C305-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of obesity has dramatically increased and poses a major threat to human health. Obesity often accompanies hyperlipemia, which is strongly related to the occurrence and development of obesity\u2010related chronic diseases. Differences in metabolomic profiling of serum between obese (with hyperlipemia) and normal\u2010weight men (<jats:italic>n<\/jats:italic> = 30 in each group) were investigated using ultrahigh\u2010pressure liquid chromatography\u2013quadrupole\u2013time of flight mass spectrometry (UHPLC\u2010Q\u2010TOF MS\/MS) and partial least\u2010squares\u2013discriminant analysis (PLS\u2010DA). Obese men showed higher levels of weight, body mass index, fat mass, systolic blood pressure, fasting plasma glucose, triglyeride, total cholesterol, insulin, HOMA\u2010IR and high\u2010sensitivity CRP. Obese and normal\u2010weight groups were clearly discriminated from each other on a PLS\u2010DA score plot and nine major metabolites contributing to the discrimination were assigned, including increased 2\u2010octenoylcarnitine, eicosadienoic acid, 12\u2010hydroperoxyeicosatetraenoic acid, 4\u2010hydroxyestrone sulfate, lysoPE[18:1(11<jats:italic>Z<\/jats:italic>)\/0:0], thromboxane B2 and pyridinoline and decreased vitamin D3 glucosiduronate and 9,10\u2010DHOME. These metabolites were associated with lipid metabolism and obesity\u2010related diseases, and reflected the metabolic differences between normal and obese men, which may be important for future clinical diagnosis, treatment and assessment of the therapeutic effect on obesity\u2010related chronic disease. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3491","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T07:43:04Z","timestamp":1433490184000},"page":"48-54","source":"Crossref","is-referenced-by-count":32,"title":["Metabolomic analysis of serum from obese adults with hyperlipemia by UHPLC\u2010Q\u2010TOF MS\/MS"],"prefix":"10.1002","volume":"30","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.03.020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2006.15.1028"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.04.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.989"},{"key":"e_1_2_7_6_1","first-page":"483","article-title":"Obese men have elevated plasma levels of estrone sulfate","volume":"14","author":"Brind J","year":"1990","journal-title":"International Journal of Obesity"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/b914182k"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650060615"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108796"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100892r"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/874981"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507621200"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2006.02.014"},{"key":"e_1_2_7_15_1","first-page":"478","article-title":"A description on the Chinese national nutrition and health survey in 2002","volume":"26","author":"Li LM","year":"2005","journal-title":"Chinese Journal of Epidemiology"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082459"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00001.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.510"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.1.76"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109979"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.7.898"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1157"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/004982599238047"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2006.01426.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.531"},{"key":"e_1_2_7_26_1","unstructured":"World Health Organization.Obesity and Overweight 2014. 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