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The pharmacokinetics of orally administered pristimerin with and without verapamil pretreatment was investigated. The results indicated that, when the rats were pretreated with verapamil, the peak concentration of pristimerin increased from 189.13 to 277.53\u2009ng\/mL (46.7%), and the AUC<jats:sub>0\u2013<jats:italic>t<\/jats:italic><\/jats:sub> increased by approximately 82.0%. Additionally, the effects of verapamil on the absorption and metabolic stability of pristimerin were investigated using the Caco\u20102 cell transwell model and rat liver microsomes. A markedly higher transport of pristimerin across the Caco\u20102 cells was observed in the basolateral\u2010to\u2010apical direction and was abrogated in the presence of the P\u2010gp inhibitor, verapamil. These results indicated that P\u2010gp might be involved in the absorption of pristimerin. Of note, the metabolic half\u2010life of pristimerin was prolonged by the pretreatment with verapamil. In conclusion, verapamil could affect the pharmacokinetics of pristimerin, and it might work through increasing the absorption of pristimerin by inhibiting P\u2010gp, or through slowing down the metabolism of pristimerin in the rat liver. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3611","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T10:22:55Z","timestamp":1441707775000},"page":"802-809","source":"Crossref","is-referenced-by-count":9,"title":["Influence of verapamil on pharmacokinetics of pristimerin in rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Xiaodong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of General Surgery Pizhou City People's Hospital  Pizhou City 221300 Jiangsu Province China"},{"name":"Department of Emergency Surgery Shanghai Putuo District Central Hospital  Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biliary Tract Surgery Department 2, Eastern Hepatobiliary Surgery Hospital Second Military Medical University  Shanghai 200430 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of orthopedics Pizhou Traditional Chinese Medicine Hospital  Pizhou City 221300 Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Changhai Hospital, Second Military Medical University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Surgery Shanghai Putuo District Central Hospital  Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Pizhou City People's Hospital  Pizhou City 221300 Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Pizhou Traditional Chinese Medicine Hospital  Pizhou City 221300 Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2325"},{"key":"e_1_2_7_3_1","first-page":"6956","article-title":"Evaluation of antioxidant capacity and synergistic associations of quinonemethide triterpenes and phenolic substances from","volume":"15","author":"Dos Santos VA","year":"2010","journal-title":"Maytenus ilicifolia (Celastraceae) Molecules"},{"key":"e_1_2_7_4_1","article-title":"Hepatic, gastric and intestinal first\u2010pass effects of vitexin\u20102\u2032\u2032\u2010O\u2010rhamnoside in rats by ultra\u2010high\u2010performance liquid chromatography","author":"Gao Y","year":"2015","journal-title":"Biomedical Chromatography"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0303619"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.691966"},{"key":"e_1_2_7_7_1","first-page":"477","article-title":"Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS\u2010mediated mitochondrial dysfunction","volume":"18","author":"Guo Y","year":"2013","journal-title":"Journal of the Balkan Union of Oncology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.06.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971480"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.1028356"},{"key":"e_1_2_7_11_1","first-page":"133","article-title":"Drug interactions \u2013 principles, examples and clinical consequences","volume":"110","author":"Lehmann K","year":"2013","journal-title":"Additional important drug interactions. 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