{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:52:28Z","timestamp":1761742348865,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,5,5]],"date-time":"2004-05-05T00:00:00Z","timestamp":1083715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A very rapid and simple MEKC method was developed for the simultaneous determination of four antiepileptic drugs, ethosuximide (Etho), primidone (Pri), phenytoin (Pht) and carbamazepine (Cbz) in human serum. Sample analysis required only 100 \u00b5L of human serum which only needed to be centrifuged, decanted and combined with the running buffer [5.3 m<jats:sc>m<\/jats:sc> Na<jats:sub>2<\/jats:sub>HPO<jats:sub>4<\/jats:sub>\/3.2 m<jats:sc>m<\/jats:sc> borax buffer (pH 9.5) containing 55 m<jats:sc>m<\/jats:sc> SDS and 3.5% (v\/v) acetone]. The analysis was performed in only 10 min into fused\u2010silica capillaries (57 cm total length with 50 \u00b5m i.d. and 50 cm to the detector) using the MEKC methodology with diode\u2010array detection at 220 nm. The calibration graphs were established for ethoximide, primidone, phenytoin and carbamazepine between 0 and 20 mg\/L. Recoveries were between 85 and 87%. The simplicity of the proposed methodology makes it suitable for routine clinical use, especially for epileptic patients on polytherapy. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.363","type":"journal-article","created":{"date-parts":[[2004,5,5]],"date-time":"2004-05-05T13:07:47Z","timestamp":1083762467000},"page":"608-612","source":"Crossref","is-referenced-by-count":12,"title":["Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum"],"prefix":"10.1002","volume":"18","author":[{"given":"Miguel Navarrete","family":"Casas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Cruces","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Segura","family":"Carretero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Fern\u00e1ndez","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00502-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(99)00167-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719308019900"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00769.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(97)00037-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)94715-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02492681"},{"issue":"5","key":"e_1_2_1_9_1","first-page":"249","volume":"19","author":"Kuelpmann WR","year":"1981","journal-title":"Journal of Clinical Biochemistry"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)87130-Z"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.117"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(93)80477-L"},{"issue":"1","key":"e_1_2_1_13_1","first-page":"391","volume":"6","author":"Liu CM","year":"1998","journal-title":"Yaowu Shipin Fenxi"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199910000-00013"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563657809150018"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150110905"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038030-00001"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199111000-00009"},{"volume-title":"A Textbook for the Clinical Application of TDM","year":"1986","author":"Taylor WJ","key":"e_1_2_1_19_1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00854-8"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199204000-00015"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050001"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82127-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240160105"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83320-4"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(85)80122-5"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:59:02Z","timestamp":1760043542000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,5]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1002\/bmc.363"],"URL":"https:\/\/doi.org\/10.1002\/bmc.363","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2004,5,5]]}}}