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Interferences from endogenous components and, if necessary, from major metabolites as well as possible co\u2010administered medications should be evaluated during a selectivity test. This paper describes a simple, rapid and cost\u2010effective HPLC\u2010UV method for the determination of naproxen in human plasma in the presence of two other analgesics, ibuprofen and paracetamol. Sample preparation is based on a simple liquid\u2013liquid extraction procedure with a short, 5\u2009s mixing time. Fenoprofen, which is characterized by a similar structure and properties to naproxen, was first used as the internal standard. The calibration curve is linear in the concentration range of 0.5\u201380.0\u2009\u00b5g\/mL, which is suitable for pharmacokinetic studies following a single 220\u2009mg oral dose of naproxen sodium. The method was fully validated according to international guidelines and was successfully applied in a bioequivalence study in humans. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.3635","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T17:17:55Z","timestamp":1444756675000},"page":"953-961","source":"Crossref","is-referenced-by-count":10,"title":["Validated HPLC\u2010UV method for determination of naproxen in human plasma with proven selectivity against ibuprofen and paracetamol"],"prefix":"10.1002","volume":"30","author":[{"given":"Monika","family":"Filist","sequence":"first","affiliation":[{"name":"Pharmaceutical Research Institute Pharmacology Department  8 Rydygiera Street 01\u2010793 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Szlaska","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw Department of Drug Chemistry  1 Banacha Street 02\u2010097 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Kaza","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Institute Pharmacology Department  8 Rydygiera Street 01\u2010793 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Pawi\u0144ski","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw Department of Drug Chemistry  1 Banacha Street 02\u2010097 Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00244-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00563009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1232-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-8-18"},{"issue":"8","key":"e_1_2_8_6_1","first-page":"589","article-title":"Comparative bioavailability of two oral suspensions of naproxen sodium","volume":"56","author":"Carrasco\u2010Portugal MC","year":"2006","journal-title":"Arzneimittel Forschung \u2013 Drug Research"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.11.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2263-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.04.012"},{"key":"e_1_2_8_10_1","unstructured":"European Medicines Agency.Guideline on the investigation of bioequivalence (CPMP\/EWP\/QWP\/1401\/98\/Rev. 1\/Corr**). 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