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The early stage of liver fibrosis was established with a single subcutaneous injection of carbon tetrachloride twice each week for 4\u2009weeks continuously. At the end of the experiment, GC\u2010TOF\/MS technology with multivariate statistical approaches such as principal component analysis, partial least squares\u2010discriminant analysis and orthogonal partial least squares\u2010discriminant analysis was used to analyze the changes in the metabolic spectrum trajectory and identify potential biomarkers. Twelve potential biomarkers in the model group, such as succinic acid, threonine and lactose, were selected, which indicate that the metabonomic pathogenesis of the early stage of liver fibrosis may be related to disorders of energy metabolism, amino acid metabolism and fatty acid metabolism.<\/jats:p>","DOI":"10.1002\/bmc.3899","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T06:32:54Z","timestamp":1479364374000},"source":"Crossref","is-referenced-by-count":13,"title":["Metabolic characterization of the early stage of hepatic fibrosis in rat using GC\u2010TOF\/MS and multivariate data analyses"],"prefix":"10.1002","volume":"31","author":[{"given":"Hui","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The first affiliated hospital of Anhui university of Chinese medicine  Hefei China"},{"name":"College of Basic Medicine Anhui Medical University  Hefei 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