{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:25:51Z","timestamp":1768703151879,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We developed and validated a high\u2010resolution liquid chromatography mass spectrometry method for the quantification of furosemide in camel plasma which was used for a pharmacokinetic study in camels. Plasma samples were extracted by supported liquid extraction and furosemide and internal standard (furosemide\u2010D5) were separated on a an Agilent Zorbax XDB C<jats:sub>18<\/jats:sub> column (50\u2009\u00d7\u20092.1\u2009mm i.d., 3.5\u2009\u03bcm). Data was acquired in full\u2010scan mode over a mass range of 200\u2013400\u2009Da in negative electrospray mode at a resolution of 70,000. Linear calibration curves were obtained over the concentration ranges of 1.0\u201310,000\u2009ng\/mL. The validated method was then successfully applied in evaluating the pharmacokinetics and metabolites of furosemide in six camels (<jats:italic>Camelus dromedarus<\/jats:italic>) and we were able to advice on a withdrawal time of furosemide treatment before racing.<\/jats:p>","DOI":"10.1002\/bmc.3902","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T05:32:55Z","timestamp":1479447175000},"source":"Crossref","is-referenced-by-count":3,"title":["Quantification of furosemide in camel plasma by high resolution mass spectrometry, application on pharmacokinetics"],"prefix":"10.1002","volume":"31","author":[{"given":"Ibrahim A.","family":"Wasfi","sequence":"first","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed A.","family":"Wajid","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Agha","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasreen A.","family":"Al Biriki","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled M.","family":"Al Neaimi","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed A.","family":"Al Ali","sequence":"additional","affiliation":[{"name":"Camel Racing Labosratory Forensic Evidence Department  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(88)91110-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90118-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1974.tb00724.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00789.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0090-9556(24)15368-8","article-title":"Input rate as a major determinant of furosemide pharmacodynamics: influence of fluid replacement and hypoalbuminemia","volume":"28","author":"Castaneda\u2010Hernandez G.","year":"2000","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0090-9556(25)08009-2","article-title":"The pharmacology of furosemide in the horse. 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Available from:http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceCompliance Regulatory Information\/Guidance s\/UCM070107.pdf"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.10.021"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3902","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.3902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:15:06Z","timestamp":1760037306000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.3902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,26]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/bmc.3902"],"URL":"https:\/\/doi.org\/10.1002\/bmc.3902","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,26]]},"article-number":"e3902"}}