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The porous surface structure of the sol\u2013gel\/Cu nanocomposite coating was revealed by scanning electron microscopy. Direct immersion SPME followed by HPLC\u2010UV determination was employed. The factors influencing the SPME procedure, such as the salt content, desorption solvent type, pH and equilibration time, were optimized. The best conditions were obtained with no salt content, acetonitrile as desorption solvent type, pH\u20099 and 10\u2009min equilibration time. The calibration graphs for urine samples showed good linearity. The detection limit was about 0.2\u2009ng mL<jats:sup>\u22121<\/jats:sup>. Also, the novel method for preparation of nanocomposite fiber was compared with previously reported techniques for MDN determination. The results show that the novel nanocomposite fiber has relatively high extraction efficiency.<\/jats:p>","DOI":"10.1002\/bmc.3926","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T01:52:40Z","timestamp":1483062760000},"source":"Crossref","is-referenced-by-count":10,"title":["Solid\u2010phase microextraction of methadone in urine samples by electrochemically co\u2010deposited sol\u2013gel\/Cu nanocomposite fiber"],"prefix":"10.1002","volume":"31","author":[{"given":"Sirwan","family":"Mohammadiazar","sequence":"first","affiliation":[{"name":"Department of Chemistry Sanandaj Branch, Islamic Azad University  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fateme","family":"Hasanli","sequence":"additional","affiliation":[{"name":"Department of Chemistry Islamic Azad University, Tehran North Branch  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Maham","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aliabad Katoul Branch, Islamic Azad University  Aliabad Katoul Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Payami Samarin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Islamic Azad University, Tehran North Branch  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.038"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200580"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100367"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.02.040"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520\u2010636X(2000)12:9<681::AID\u2010CHIR7>3.0.CO;2\u2010J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.128386"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260450029025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2013.01.052"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.12.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700067"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.12.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.04.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.04.088"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0379\u20100738(03)00098\u20107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2356"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010014\u20107727\u20106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2003.02053.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.05.042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.01.038"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.06.072"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.05.023"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2012.03.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.11.035"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.03.039"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0376\u20108716(99)00104\u20100"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac301305u"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/c003335a"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20104347(00)00344\u20103"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201500636"},{"key":"e_1_2_7_32_1","unstructured":"The World Anti\u2010Doping Code International Standard. 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