{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:22:25Z","timestamp":1762917745557,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 6\u2010<jats:italic>O\u2010<\/jats:italic>sulfate ester of morphine (M6S) has previously been shown to be an analgesic with greater potency and fewer side effects than morphine. However, being a sulfate ester derivative of morphine, the question exists as to whether this compound is stable in biological fluids and tissues with regard to pH\u2010 and esterase\u2010mediated degradation. To date, no studies have focused on the stability profile of M6S across the physiologically relevant pH range of 1.2\u20137.4. In addition, the stability of M6S is not known in rat plasma and rat brain homogenate, or in simulated rat gastric and intestinal fluids. This study determines the stability profile of M6S (utilized as the sodium salt) and demonstrates that M6S is highly stable and resilient to either enzymatic\u2010 or pH\u2010dependent hydrolysis <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/bmc.3957","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T22:02:44Z","timestamp":1487196164000},"source":"Crossref","is-referenced-by-count":5,"title":["Stability studies of potent opioid analgesic, morphine\u20106\u2010<i>O\u2010<\/i>sulfate in various buffers and biological matrices by HPLC\u2010DAD analysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Jai Shankar K.","family":"Yadlapalli","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaineb A.F.","family":"Albayati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narasimha R.","family":"Penthala","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard P.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-6150","authenticated-orcid":false,"given":"Peter A.","family":"Crooks","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.09.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600740804"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.05.060"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.05.004"},{"key":"e_1_2_5_6_1","unstructured":"FDA Guidance: Guidance for Industry.Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. (2012).http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM193282.pdf."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.08.034"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02067-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.25.497"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20035"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03528-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3226"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(72)90003-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00381-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00380-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90619-3"},{"key":"e_1_2_5_17_1","first-page":"1","article-title":"Morphine 6\u2010O\u2010sulfate sodium: A novel opioid therapeutic alternative evaluated in a rat model of diabetic neuropathy, its pharmacological characterization and blood brain barrier permeability","volume":"1","author":"Yadlapalli J. K.","year":"2014","journal-title":"2014 AAPS Annual Meeting"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.012"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01766-7"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.3957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.3957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:51:10Z","timestamp":1760046670000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.3957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/bmc.3957"],"URL":"https:\/\/doi.org\/10.1002\/bmc.3957","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2017,3,24]]},"article-number":"e3957"}}