{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:30:41Z","timestamp":1789475441628,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,26]],"date-time":"2017-03-26T00:00:00Z","timestamp":1490486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373083"],"award-info":[{"award-number":["81373083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary angle\u2010closure glaucoma (PACG) is a severe chronic neurodegenerative disease in Asia. Identification of important metabolites associated with PACG is crucial for early intervention and advancing knowledge of the disease mechanism. We applied gas chromatography\u2013mass spectrometry (GC\u2010MS) for targeted metabolomic analysis on serum samples from 38 newly diagnosed PACG patients and 48 controls. Palmitoleic acid (PA), linoleic acid (LA), <jats:italic>\u03b3<\/jats:italic>\u2010linolenic acid (GLA) and arachidonic acid (ARA) were identified as important metabolites associated with PACG. PA and GLA were significantly elevated (<jats:italic>p<\/jats:italic> &lt; 0.05), while LA and ARA showed a significantly decreased trend (<jats:italic>p<\/jats:italic> &lt; 0.05) in PACG group compared with the control group. Also, significant negative correlations were observed between LA and ARA levels and intraocular pressure of the left eye (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.750, <jats:italic>p<\/jats:italic> &lt; 0.001; <jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.729, <jats:italic>p<\/jats:italic> &lt; 0.001) and the right eye (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.786, <jats:italic>p<\/jats:italic> &lt; 0.001; <jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.764, <jats:italic>p<\/jats:italic> &lt; 0.001). Serum GLA level was positively correlated with intraocular pressure of the left eye (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.233, <jats:italic>p<\/jats:italic> = 0.031) and the right eye (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.226, <jats:italic>p<\/jats:italic> = 0.036). Our findings revealed a significant difference of the serum free fatty acid metabolic profiles between PACG patients and control subjects. Furthermore, PA, LA, ARA and GLA appear to have clinical applications for the screening of PACG.<\/jats:p>","DOI":"10.1002\/bmc.3963","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T14:02:42Z","timestamp":1487426562000},"source":"Crossref","is-referenced-by-count":27,"title":["Long\u2010chain unsaturated fatty acids as possible important metabolites for primary angle\u2010closure glaucoma based on targeted metabolomic analysis"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-0071","authenticated-orcid":false,"given":"Shengzhong","family":"Rong","sequence":"first","affiliation":[{"name":"School of Public Health Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Guan","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Foreign Language Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mucong","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Public Health Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Public Health Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zou","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Mudanjiang Medical University  Mudanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.07.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035102"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ajcn\/11.2.142","article-title":"The influence of diet on fecal lipids in south African white and bantu prisoners","volume":"11","author":"Antonis A.","year":"1962","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/46.1.41"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16702"},{"key":"e_1_2_7_7_1","first-page":"91","article-title":"Dietary deficiency of N\u20103 fatty acids alters rhodopsin content and function in the rat retina","volume":"35","author":"Bush R. 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