{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:44:08Z","timestamp":1773211448715,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Translational Medicine (INCT-TM)"},{"name":"Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC)"},{"name":"CNPq (JQ, FDP, GZR and FHR)"},{"name":"FAPESC (JQ, FDP and FHR)"},{"DOI":"10.13039\/501100013379","name":"Instituto C\u00e9rebro e Mente","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013379","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UNESC (JQ and FDP)"},{"name":"Department of Psychiatry and Behavioral Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is increasing interest in natural antioxidants that are candidates for the prevention of brain damage occurring in major depressive disorders. <jats:styled-content style=\"fixed-case\"><jats:italic>Cecropia pachystachya<\/jats:italic><\/jats:styled-content> is a tropical tree species of Central and South America and a rich source of polyphenols, particularly flavonoids. The aim of this study was to characterize the flavonoid profile of an enriched flavonoid fraction of <jats:styled-content style=\"fixed-case\"><jats:italic>C. pachystachya<\/jats:italic><\/jats:styled-content> (EFF\u2010<jats:italic>Cp<\/jats:italic>) and evaluate the antidepressant\u2010like effects of its acute administration in behavior, cytokine levels, oxidative stress and energy metabolism parameters<jats:italic>.<\/jats:italic> The EFF\u2010<jats:italic>Cp<\/jats:italic> chemical characterization was performed by HPLC\/DAD and LC\/QTOF. The antidepressant\u2010like effects were performed by the forced swimming test, splash test and open field test. EFF\u2010<jats:italic>Cp<\/jats:italic> revealed 15 flavonoids, including seven new glycosyl flavonoids for <jats:styled-content style=\"fixed-case\"><jats:italic>C. pachystachya<\/jats:italic><\/jats:styled-content>. Quantitatively, EFF\u2010<jats:italic>Cp<\/jats:italic> showed isoorientin (43.46\u2009mg\/g), orientin (23.42\u2009mg\/g) and isovitexin (17.45\u2009mg\/g) as major <jats:italic>C<\/jats:italic>\u2010glycosyl flavonoids. In addition, EFF\u2010<jats:italic>Cp<\/jats:italic> at doses 50 and 100\u2009mg\/kg reduced the immobility time in the forced swimming test, without changing the locomotor activity and grooming time. In addition, EFF\u2010<jats:italic>Cp<\/jats:italic> was able to prevent the oxidative damage in some brain areas. In conclusion, the results of this study suggest that EFF\u2010<jats:italic>Cp<\/jats:italic> exerts antidepressant\u2010like effects with its antioxidant properties.<\/jats:p>","DOI":"10.1002\/bmc.3982","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T03:42:43Z","timestamp":1490931763000},"source":"Crossref","is-referenced-by-count":22,"title":["LC\/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of <scp><i>Cecropia pachystachya<\/i><\/scp> Tr\u00e9cul leaves with potential antidepressant\u2010like activity"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-2869","authenticated-orcid":false,"given":"Caroline Flach","family":"Ortmann","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Farm\u00e1cia Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina 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