{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:55:45Z","timestamp":1760061345454,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["NCN 2013\/11\/B\/N25\/00118"],"award-info":[{"award-number":["NCN 2013\/11\/B\/N25\/00118"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["NCN 2013\/11\/B\/N25\/00118"],"award-info":[{"award-number":["NCN 2013\/11\/B\/N25\/00118"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gas chromatography\u2013mass spectrometry is a preferred method for fatty acid (FA) analysis in biofluids from patients with metabolic diseases. Complex characteristics of FAs make their analysis particularly challenging. Selection of an appropriate chromatographic column is particularly important component of the process as it provides optimal separation and detection of possibly all FAs present in the sample. However, no accurate protocol for comparative evaluation of capillary columns for the analysis of whole serum FA profile in patients with chronic kidney disease (CKD) has been developed thus far. Therefore, in the present study four columns were examined to select the one providing optimal separation and determination of FA profiles in this group of patients. Moreover, serum FA profiles obtained with the selected column in CKD patients subjected to peritoneal dialysis and healthy controls were compared. Thirty\u2010seven component FAME Mix and sera from CKD patients were used to optimize chromatographic conditions and to select the most appropriate column. The ZB\u20105 column turned out to be the most appropriate for the analysis of whole FA profile in CKD patients' sera. Then, this column was used to compare FA profiles in patients subjected to peritoneal dialysis and in healthy controls. The analysis demonstrated many abnormalities in the FA profile of CKD patients. Further studies involving larger groups of patients presenting with other stages of CKD are required to explain the impact of the disease progression on composition of serum FAs.<\/jats:p>","DOI":"10.1002\/bmc.4006","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T12:04:21Z","timestamp":1494504261000},"source":"Crossref","is-referenced-by-count":5,"title":["Suitability of selected chromatographic columns for analysis of fatty acids in dialyzed patients"],"prefix":"10.1002","volume":"31","author":[{"given":"Magdalena","family":"Pazda","sequence":"first","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Stepnowski","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Sledzinski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry Medical University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Chmielewski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Trasplantology and Internal Medicine Medical University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-5652","authenticated-orcid":false,"given":"Adriana","family":"Mika","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry University of Gdansk  Poland"},{"name":"Department of Pharmaceutical Biochemistry Medical University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2009.01.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095360"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.12.039"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00142-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00596-010-0188-9"},{"key":"e_1_2_7_9_1","first-page":"91","article-title":"Gas chromatography\u2013mass spectrometry of biofluids and extracts","volume":"1277","author":"Emwas A. 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