{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:36:33Z","timestamp":1768822593511,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Through blocking the cardiac persistent sodium current, riluzole has the potential to prevent myocardial damage post cardiac bypass surgery. A sensitive UHPLC\u2013MS\/MS method was developed and validated for quantitation of riluzole and 5\u2010methoxypsoralen in human plasma and myocardial tissue homogenate using a liquid\u2013liquid extraction with dichloromethane. The chromatographic separation was achieved using Shimadzu Shim\u2010pack XR\u2010ODS III, 2.0 \u00d7 50 mm, 1.6 \u03bcm column with a gradient mobile phase comprising methanol and ammonium acetate buffer pH 3.6 in purified water. The analyte and internal standard were separated within 3.5 min. Riluzole quantitation was achieved using the mass transitions of 235\u2013138 for riluzole and 217\u2013156 for 5\u2010methoxypsoralen. The method was linear for riluzole plasma concentrations from 0.2 to 500 ng\/mL and myocardial tissue homogenate concentrations from 0.2 to 100 ng\/mL. The method developed was successfully applied to a clinical study for patients receiving riluzole while undergoing cardiac bypass surgery.<\/jats:p>","DOI":"10.1002\/bmc.4030","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T17:40:47Z","timestamp":1497721247000},"source":"Crossref","is-referenced-by-count":2,"title":["A validated UHPLC\u2013MS\/MS method for the measurement of riluzole in plasma and myocardial tissue samples"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-7475","authenticated-orcid":false,"given":"Suzanne L.","family":"Parker","sequence":"first","affiliation":[{"name":"Burns, Trauma and Critical Care Research Centre The University of Queensland, UQ Centre for Clinical Research  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yarmarly C.","family":"Guerra Valero","sequence":"additional","affiliation":[{"name":"Burns, Trauma and Critical Care Research Centre The University of Queensland, UQ Centre for Clinical Research  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Lipman","sequence":"additional","affiliation":[{"name":"Burns, Trauma and Critical Care Research Centre The University of Queensland, UQ Centre for Clinical Research  Brisbane Australia"},{"name":"Department of Intensive Care Medicine Royal Brisbane &amp; Women's Hospital  Brisbane Australia"},{"name":"Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Weiss","sequence":"additional","affiliation":[{"name":"Medical School, College of Medicine, Biology and Environment Australian National University  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Smith","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedic Research Unit Canberra Hospital  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndal","family":"Russell","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedic Research Unit Canberra Hospital  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Smith","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedic Research Unit Canberra Hospital  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Burns, Trauma and Critical Care Research Centre The University of Queensland, UQ Centre for Clinical Research  Brisbane Australia"},{"name":"Department of Intensive Care Medicine Royal Brisbane &amp; Women's Hospital  Brisbane Australia"},{"name":"School of Pharmacy The University of Queensland  Brisbane Australia"},{"name":"Department of Pharmacy Royal Brisbane &amp; Women's Hospital  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Wallis","sequence":"additional","affiliation":[{"name":"Burns, Trauma and Critical Care Research Centre The University of Queensland, UQ Centre for Clinical Research  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652040-00010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-4034-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.01.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.11.053"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AY00583J"},{"key":"e_1_2_8_7_1","unstructured":"Royal Society of Chemistry(2014).ChemSpider.http:\/\/www.chemspider.com\/"},{"key":"e_1_2_8_8_1","unstructured":"Sanofi\u2010Aventis US(2008).Rilutek (riluzole) Tablets. Bridgewater NJ."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2010.506936"},{"key":"e_1_2_8_10_1","unstructured":"US Food and Drug Administration(2013).Draft guidance for industry Bioanalytical method validation. 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